Synthetic biology of fungal natural products

Synthetic biology is an ever-expanding field in science, also encompassing the research area of fungal natural product (NP) discovery and production. Until now, different aspects of synthetic biology have been covered in fungal NP studies from the manipulation of different regulatory elements and he...

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Published inFrontiers in microbiology Vol. 6; p. 775
Main Authors Mattern, Derek J, Valiante, Vito, Unkles, Shiela E, Brakhage, Axel A
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 30.07.2015
Subjects
Engineering of Biosynthetic Enzymes
fungal natural products
heterologous expression
Microbiology
Regulation of Natural Products
Synthetic Biology
fungal natural products
synthetic biology
heterologous expression
engineering of biosynthetic enzymes
regulation of natural products
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Summary:Synthetic biology is an ever-expanding field in science, also encompassing the research area of fungal natural product (NP) discovery and production. Until now, different aspects of synthetic biology have been covered in fungal NP studies from the manipulation of different regulatory elements and heterologous expression of biosynthetic pathways to the engineering of different multidomain biosynthetic enzymes such as polyketide synthases or non-ribosomal peptide synthetases. The following review will cover some of the exemplary studies of synthetic biology in filamentous fungi showing the capacity of these eukaryotes to be used as model organisms in the field. From the vast array of different NPs produced to the ease for genetic manipulation, filamentous fungi have proven to be an invaluable source for the further development of synthetic biology tools.
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This article was submitted to Microbial Physiology and Metabolism, a section of the journal Frontiers in Microbiology.
Reviewed by: Monika Schmoll, AIT Austrian Institute of Technology, Austria; Junbiao Dai, Tsinghua University, China; Xiaoqiang Jia, Tianjin University, China
Edited by: Ana L. Leitão, Universidade Nova de Lisboa, Portugal
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2015.00775