Olax scandens Mediated Biogenic Synthesis of Ag-Cu Nanocomposites: Potential Against Inhibition of Drug-Resistant Microbes
In the present study, we have synthesized silver-copper nanocomposites (Ag-Cu NCs) using an leaf extract (green synthesis method) and evaluated their antimicrobial potential against less susceptible pathogens. The kinetics of Ag-Cu NCs synthesis was followed by UV-VIS and fluorescence spectroscopy....
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| Published in | Frontiers in chemistry Vol. 8; p. 103 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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| Abstract | In the present study, we have synthesized silver-copper nanocomposites (Ag-Cu NCs) using an
leaf extract (green synthesis method) and evaluated their antimicrobial potential against less susceptible pathogens. The kinetics of Ag-Cu NCs synthesis was followed by UV-VIS and fluorescence spectroscopy. The physicochemical characterization of as-synthesized Ag-Cu NCs was executed using electron microscopy, Energy Dispersive X-Ray, Fourier Transform Infrared Spectroscopy, and a Differential Light Scattering method. As-synthesized Ag-Cu NCs induced the formation of Reactive Oxygen Species (ROS), thereby causing alteration and decrementation of cellular proteins, DNA, lipids, etc., and eventually leading to cell death, as determined by a Live/Dead assay. Next, we assessed the anti-biofilm potential of as-synthesized Ag-Cu NCs against biofilm forming bacteria. The as-synthesized Ag-Cu NCs, when compared to monometallic silver nanoparticles, exhibited significantly higher anti-microbial activity against both sensitive as well as drug resistant microbial isolates. |
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| AbstractList | In the present study, we have synthesized silver-copper nanocomposites (Ag-Cu NCs) using an
leaf extract (green synthesis method) and evaluated their antimicrobial potential against less susceptible pathogens. The kinetics of Ag-Cu NCs synthesis was followed by UV-VIS and fluorescence spectroscopy. The physicochemical characterization of as-synthesized Ag-Cu NCs was executed using electron microscopy, Energy Dispersive X-Ray, Fourier Transform Infrared Spectroscopy, and a Differential Light Scattering method. As-synthesized Ag-Cu NCs induced the formation of Reactive Oxygen Species (ROS), thereby causing alteration and decrementation of cellular proteins, DNA, lipids, etc., and eventually leading to cell death, as determined by a Live/Dead assay. Next, we assessed the anti-biofilm potential of as-synthesized Ag-Cu NCs against biofilm forming bacteria. The as-synthesized Ag-Cu NCs, when compared to monometallic silver nanoparticles, exhibited significantly higher anti-microbial activity against both sensitive as well as drug resistant microbial isolates. In the present study, we have synthesized silver-copper nanocomposites (Ag-Cu NCs) using an Olax scandens leaf extract (green synthesis method) and evaluated their antimicrobial potential against less susceptible pathogens. The kinetics of Ag-Cu NCs synthesis was followed by UV-VIS and fluorescence spectroscopy. The physicochemical characterization of as-synthesized Ag-Cu NCs was executed using electron microscopy, Energy Dispersive X-Ray, Fourier Transform Infrared Spectroscopy, and a Differential Light Scattering method. As-synthesized Ag-Cu NCs induced the formation of Reactive Oxygen Species (ROS), thereby causing alteration and decrementation of cellular proteins, DNA, lipids, etc., and eventually leading to cell death, as determined by a Live/Dead assay. Next, we assessed the anti-biofilm potential of as-synthesized Ag-Cu NCs against biofilm forming bacteria. The as-synthesized Ag-Cu NCs, when compared to monometallic silver nanoparticles, exhibited significantly higher anti-microbial activity against both sensitive as well as drug resistant microbial isolates. In the present study, we have synthesized silver-copper nanocomposites (Ag-Cu NCs) using an Olax scandens leaf extract (green synthesis method) and evaluated their antimicrobial potential against less susceptible pathogens. The kinetics of Ag-Cu NCs synthesis was followed by UV-VIS and fluorescence spectroscopy. The physicochemical characterization of as-synthesized Ag-Cu NCs was executed using electron microscopy, Energy Dispersive X-Ray, Fourier Transform Infrared Spectroscopy, and a Differential Light Scattering method. As-synthesized Ag-Cu NCs induced the formation of Reactive Oxygen Species (ROS), thereby causing alteration and decrementation of cellular proteins, DNA, lipids, etc., and eventually leading to cell death, as determined by a Live/Dead assay. Next, we assessed the anti-biofilm potential of as-synthesized Ag-Cu NCs against biofilm forming bacteria. The as-synthesized Ag-Cu NCs, when compared to monometallic silver nanoparticles, exhibited significantly higher anti-microbial activity against both sensitive as well as drug resistant microbial isolates. |
| Author | Khan, Nuha Abeer Jamal, Fauzia Alshameri, Ansam Wadia Faid Mujeeb, Anzar Abdul Badre Alam, Khan Farheen Kazmi, Shadab Ghazi, Irfan Saeed, Haris Kashif, Mohammad Owais, Mohammad |
| AuthorAffiliation | 3 Department of Biochemistry, School of Life Sciences, University of Hyderabad , Hyderabad , India 2 Plant Molecular Biology and Genetic Engineering Division, The National Botanical Research Institute, Council of Scientific and Industrial Research , Lucknow , India 1 Interdisciplinary Biotechnology Unit, Aligarh Muslim University , Aligarh , India |
| AuthorAffiliation_xml | – name: 2 Plant Molecular Biology and Genetic Engineering Division, The National Botanical Research Institute, Council of Scientific and Industrial Research , Lucknow , India – name: 3 Department of Biochemistry, School of Life Sciences, University of Hyderabad , Hyderabad , India – name: 1 Interdisciplinary Biotechnology Unit, Aligarh Muslim University , Aligarh , India |
| Author_xml | – sequence: 1 givenname: Anzar Abdul surname: Mujeeb fullname: Mujeeb, Anzar Abdul organization: Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India – sequence: 2 givenname: Nuha Abeer surname: Khan fullname: Khan, Nuha Abeer organization: Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India – sequence: 3 givenname: Fauzia surname: Jamal fullname: Jamal, Fauzia organization: Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India – sequence: 4 givenname: Khan Farheen surname: Badre Alam fullname: Badre Alam, Khan Farheen organization: Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India – sequence: 5 givenname: Haris surname: Saeed fullname: Saeed, Haris organization: Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India – sequence: 6 givenname: Shadab surname: Kazmi fullname: Kazmi, Shadab organization: Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India – sequence: 7 givenname: Ansam Wadia Faid surname: Alshameri fullname: Alshameri, Ansam Wadia Faid organization: Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India – sequence: 8 givenname: Mohammad surname: Kashif fullname: Kashif, Mohammad organization: Plant Molecular Biology and Genetic Engineering Division, The National Botanical Research Institute, Council of Scientific and Industrial Research, Lucknow, India – sequence: 9 givenname: Irfan surname: Ghazi fullname: Ghazi, Irfan organization: Department of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India – sequence: 10 givenname: Mohammad surname: Owais fullname: Owais, Mohammad organization: Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32185160$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2020 Mujeeb, Khan, Jamal, Badre Alam, Saeed, Kazmi, Alshameri, Kashif, Ghazi and Owais. Copyright © 2020 Mujeeb, Khan, Jamal, Badre Alam, Saeed, Kazmi, Alshameri, Kashif, Ghazi and Owais. 2020 Mujeeb, Khan, Jamal, Badre Alam, Saeed, Kazmi, Alshameri, Kashif, Ghazi and Owais |
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| Keywords | anti-biofilm potential Ag-Cu NCs reactive oxygen species (ROS) biogenic antimicrobial potential |
| Language | English |
| License | Copyright © 2020 Mujeeb, Khan, Jamal, Badre Alam, Saeed, Kazmi, Alshameri, Kashif, Ghazi and Owais. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Snippet | In the present study, we have synthesized silver-copper nanocomposites (Ag-Cu NCs) using an
leaf extract (green synthesis method) and evaluated their... In the present study, we have synthesized silver-copper nanocomposites (Ag-Cu NCs) using an Olax scandens leaf extract (green synthesis method) and evaluated... In the present study, we have synthesized silver-copper nanocomposites (Ag-Cu NCs) using an Olax scandens leaf extract (green synthesis method) and evaluated... |
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| SubjectTerms | Ag-Cu NCs anti-biofilm potential antimicrobial potential biogenic Chemistry reactive oxygen species (ROS) |
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| Title | Olax scandens Mediated Biogenic Synthesis of Ag-Cu Nanocomposites: Potential Against Inhibition of Drug-Resistant Microbes |
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