Synthesis, Antiviral, and Antimicrobial Evaluation of Benzyl Protected Diversified C -nucleosides

Formyl glycals are the versatile synthetic intermediates and can serves as precursor for the synthesis of various C and N-nucleosides. Due to the presence of electron donating and electron withdrawing character on formyl sugars which makes the molecule more susceptible to nucleophilic attack. Utiliz...

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Published inFrontiers in chemistry Vol. 6; p. 294
Main Authors Bari, Ahmed, Ali, Syed S, Alanazi, Amer M, Mashwani, Muhammad A, Al-Obaid, Abdulrahman M
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 19.07.2018
Subjects
Chemistry
formyl glycal
formyl rhamnal
nucleosides
ring transformation
villsmeir-haack
nucleosides
formyl rhamnal
villsmeir-haack
ring transformation
formyl glycal
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Summary:Formyl glycals are the versatile synthetic intermediates and can serves as precursor for the synthesis of various C and N-nucleosides. Due to the presence of electron donating and electron withdrawing character on formyl sugars which makes the molecule more susceptible to nucleophilic attack. Utilizing same strategy, we propose the synthesis of diversified -nucleosides ( - ) by reaction with , dinucleophiles. These nucleoside analogs were than tested against viral, bacterial and fungal strains.
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Reviewed by: Christophe Len, University of Technology of Compiègne, France; Christophe Salome, SpiroChem AG, Switzerland
This article was submitted to Medicinal and Pharmaceutical Chemistry, a section of the journal Frontiers in Chemistry
Edited by: Laurent G. Désaubry, Université de Strasbourg, France
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2018.00294