Close relationship between serum hyaluronan levels and vascular function in patients with type 2 diabetes

• Published in: Biomarkers Vol. 19; no. 6; pp. 493 - 497
• Main Authors: Morita, Miwa, Yano, Shozo, Ishibashi, Yutaka, Nakata, Noriko, Kurioka, Soichi, Sugimoto, Toshitsugu
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.09.2014; Taylor & Francis
• Subjects: Aged; Biomarkers - blood; Brachial Artery - physiopathology; Cross-Sectional Studies; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - physiopathology; Female; Humans; hyaluronan; Hyaluronic Acid - blood; Male; Middle Aged; vascular function; Vasodilation; vascular function; hyaluronan; Diabetes
• ISSN: 1354-750X; 1366-5804
• DOI: 10.3109/1354750X.2014.940502

Abstract Objective: To clarify the relationship between serum hyaluronan levels and vascular function in type 2 diabetic patients. Methods: A cross-sectional cohort study. Results: In multivariate regression analysis, endothelium-dependent flow-mediated dilation was associated with age and duration of diabetes, but not with serum hyaluronan level, while endothelium-independent nitroglycerine-mediated dilation (NMD) was only associated with serum hyaluronan level (standardized estimate = −0.401, p = 0.003). NMD in the lowest tertile of hyaluronan level was significantly higher than the other tertiles (15.9% versus 12.5% and 10.4%, p = 0.047 and p = 0.002, respectively). Conclusions: Serum hyaluronan level may be useful as a surrogate marker for early changes in the vascular function, which often occurs in patients with diabetes mellitus.