Psychophysical Evaluation of Sensory Reweighting in Bilateral Vestibulopathy

• Published in: Frontiers in neurology Vol. 9; p. 377
• Main Authors: Medendorp, W. Pieter, Alberts, Bart B. G. T., Verhagen, Wim I. M., Koppen, Mathieu, Selen, Luc P. J.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 25.05.2018
• Subjects: bilateral vestibular areflexia; multisensory integration; Neuroscience; rod-and-frame; sensory reweighting; spatial orientation; vertical perception; multisensory integration; rod-and-frame; sensory reweighting; bilateral vestibular areflexia; psychophysics; spatial orientation; Bayesian integration; vertical perception
• ISSN: 1664-2295; 1664-2295
• DOI: 10.3389/fneur.2018.00377

Perception of spatial orientation is thought to rely on the brain's integration of visual, vestibular, proprioceptive, and somatosensory signals, as well as internal beliefs. When one of these signals breaks down, such as the vestibular signal in bilateral vestibulopathy, patients start compensating by relying more on the remaining cues. How these signals are reweighted in this integration process is difficult to establish, since they cannot be measured in isolation during natural tasks, are inherently noisy, and can be ambiguous or in conflict. Here, we review our recent work, combining experimental psychophysics with a reverse engineering approach, based on Bayesian inference principles, to quantify sensory noise levels and optimal (re)weighting at the individual subject level, in both patients with bilateral vestibular deficits and healthy controls. We show that these patients reweight the remaining sensory information, relying more on visual and other nonvestibular information than healthy controls in the perception of spatial orientation. This quantification approach could improve diagnostics and prognostics of multisensory integration deficits in vestibular patients, and contribute to an evaluation of rehabilitation therapies directed toward specific training programs.