Interdependence of oxysterols with cholesterol profiles in multiple sclerosis

To investigate levels of oxysterols in healthy control (HC) and multiple sclerosis (MS) patients and their interdependence with demographic, clinical characteristics, and cholesterol biomarkers. This study included 550 subjects (203 HC, 221 relapsing-remitting MS (RR-MS), 126 progressive MS (P-MS))....

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Published inMultiple sclerosis Vol. 23; no. 6; p. 792
Main Authors Mukhopadhyay, Shreya, Fellows, Kelly, Browne, Richard W, Khare, Prachi, Krishnan Radhakrishnan, Sandhya, Hagemeier, Jesper, Weinstock-Guttman, Bianca, Zivadinov, Robert, Ramanathan, Murali
Format Journal Article
LanguageEnglish
Published England 01.05.2017
Subjects
Adult
Female
Humans
Lipoproteins - blood
Male
Middle Aged
Multiple Sclerosis, Chronic Progressive - blood
Multiple Sclerosis, Relapsing-Remitting - blood
Oxysterols - blood
Prospective Studies
Proton Magnetic Resonance Spectroscopy
immunology
Multiple sclerosis
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Summary:To investigate levels of oxysterols in healthy control (HC) and multiple sclerosis (MS) patients and their interdependence with demographic, clinical characteristics, and cholesterol biomarkers. This study included 550 subjects (203 HC, 221 relapsing-remitting MS (RR-MS), 126 progressive MS (P-MS)). A complete lipid profile including total cholesterol (TC); high-density lipoprotein-cholesterol (HDL-C); low-density lipoprotein-cholesterol (LDL-C); apolipoproteins (Apo) A1, A2, B, and E; C-reactive protein (CRP); 24-hydroxycholesterol (HC); 25-HC; 27-HC; 7α-HC; and 7-ketocholesterol (KC) was obtained. Lipoprotein particle sizing by proton nuclear magnetic resonance (H NMR) was available for 432 subjects. The levels of 24-HC, 27-HC, and 7α-HC (all p < 0.015) were lower in MS compared to HC, and 7-KC was higher in P-MS compared to RR-MS ( p < 0.001). TC, LDL-C, and ApoB were associated with higher levels of all oxysterols (all p < 0.05) in HC. In MS, LDL-C was associated with higher levels of 24-HC, 25-HC, 7-KC, and 7α-HC (all p < 0.05), while TC and ApoB were associated with increased levels of all oxysterols (all p < 0.005). The findings of lower 24-HC, 27-HC, and 7α-HC in MS compared to HC and higher 7-KC in P-MS compared to RR-MS indicate that the oxysterol network is disrupted in MS.
ISSN:1477-0970
DOI:10.1177/1352458516666187