Dissecting the Vesicular Trafficking Function of IFT Subunits

Intraflagellar transport (IFT) was initially identified as a transport machine with multiple protein subunits, and it is essential for the assembly, disassembly, and maintenance of cilium/flagellum, which serves as the nexus of extracellular-to-intracellular signal integration. To date, in addition...

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Published inFrontiers in cell and developmental biology Vol. 7; p. 352
Main Authors Yang, Huihui, Huang, Kaiyao
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 15.01.2020
Subjects
Cell and Developmental Biology
ciliopathy
cilium
flagellum
IFT
vesicular trafficking
cilium
vesicular trafficking
flagellum
IFT
ciliopathy
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Summary:Intraflagellar transport (IFT) was initially identified as a transport machine with multiple protein subunits, and it is essential for the assembly, disassembly, and maintenance of cilium/flagellum, which serves as the nexus of extracellular-to-intracellular signal integration. To date, in addition to its well-established and indispensable roles in ciliated cells, most IFT subunits have presented more general functions of vesicular trafficking in the non-ciliated cells. Thus, this review aims to summarize the recent progress on the vesicular trafficking functions of the IFT subunits and to highlight the issues that may arise in future research.
Bibliography:ObjectType-Article-2
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Edited by: Junmin Pan, Tsinghua University, China
Reviewed by: Ruben Claudio Aguilar, Purdue University, United States; Gert Jansen, Erasmus University Rotterdam, Netherlands; Cosima T. Baldari, University of Siena, Italy
This article was submitted to Membrane Traffic, a section of the journal Frontiers in Cell and Developmental Biology
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2019.00352