Genetic Models of Leukemia in Zebrafish

The zebrafish animal model is gaining increasing popularity as a tool for studying human disease. Over the past 15 years, many models of leukemia and other hematological malignancies have been developed in the zebrafish. These confer some significant advantages over similar models in other animals a...

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Bibliographic Details
Published inFrontiers in cell and developmental biology Vol. 6; p. 115
Main Authors Baeten, Jeremy T, de Jong, Jill L O
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 20.09.2018
Subjects
ALL
AML
animal models
leukemia
MDS
Physiology
zebrafish
AML
ALL
leukemia
animal models
MPN
zebrafish
MDS
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Summary:The zebrafish animal model is gaining increasing popularity as a tool for studying human disease. Over the past 15 years, many models of leukemia and other hematological malignancies have been developed in the zebrafish. These confer some significant advantages over similar models in other animals and systems, representing a powerful resource for investigation of the molecular basis of human leukemia. This review discusses the various zebrafish models of lymphoid and myeloid leukemia available, the major discoveries that have been made possible by them, and opportunities for future exploration.
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This article was submitted to Molecular Medicine, a section of the journal Frontiers in Cell and Developmental Biology
Edited by: Rebecca Ann Wingert, University of Notre Dame, United States
Reviewed by: Lasse Dahl Ejby Jensen, Linköping University, Sweden; Eirini Trompouki, Max-Planck-Institut für Immunbiologie und Epigenetik, Germany
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2018.00115