Application of the Nano-Drug Delivery System in Treatment of Cardiovascular Diseases

Cardiovascular diseases (CVDs) have become a serious threat to human life and health. Though many drugs acting via different mechanism of action are available in the market as conventional formulations for the treatment of CVDs, they are still far from satisfactory due to poor water solubility, low...

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Published inFrontiers in bioengineering and biotechnology Vol. 7; p. 489
Main Authors Deng, Yudi, Zhang, Xudong, Shen, Haibin, He, Qiangnan, Wu, Zijian, Liao, Wenzhen, Yuan, Miaomiao
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 31.01.2020
Subjects
application progress
Bioengineering and Biotechnology
cardiovascular disease
nano-drug delivery system
safety
targeting strategy
cardiovascular disease
application progress
nano-drug delivery system
targeting strategy
safety
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Summary:Cardiovascular diseases (CVDs) have become a serious threat to human life and health. Though many drugs acting via different mechanism of action are available in the market as conventional formulations for the treatment of CVDs, they are still far from satisfactory due to poor water solubility, low biological efficacy, non-targeting, and drug resistance. Nano-drug delivery systems (NDDSs) provide a new drug delivery method for the treatment of CVDs with the development of nanotechnology, demonstrating great advantages in solving the above problems. Nevertheless, there are some problems about NDDSs need to be addressed, such as cytotoxicity. In this review, the types and targeting strategies of NDDSs were summarized, and the new research progress in the diagnosis and therapy of CVDs in recent years was reviewed. Future prospective for nano-carriers in drug delivery for CVDs includes gene therapy, in order to provide more ideas for the improvement of cardiovascular drugs. In addition, its safety was also discussed in the review.
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This article was submitted to Nanobiotechnology, a section of the journal Frontiers in Bioengineering and Biotechnology
These authors have contributed equally to this work
Edited by: Wenguo Cui, School of Medicine, Shanghai Jiao Tong University, China
Reviewed by: Jian Zhong, Shanghai Ocean University, China; Zhilu Yang, Southwest Jiaotong University, China
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2019.00489