Morphine Addiction and Oxidative Stress: The Potential Effects of Thioredoxin-1

Long-term administration of morphine for the management of chronic pain will result in tolerance to its analgesic effect and could even cause drug dependence. Numerous studies have demonstrated significant redox alteration in morphine dependence and addiction. Thioredoxin-1 (Trx-1) play important ro...

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Published inFrontiers in pharmacology Vol. 11; p. 82
Main Authors Zeng, Xian-Si, Geng, Wen-Shuo, Wang, Zhan-Qi, Jia, Jin-Jing
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 21.02.2020
Subjects
CPP
geranylgeranylacetone
morphine addiction
oxidative stress
Pharmacology
thioredoxin-1
morphine addiction
CPP
thioredoxin-1
geranylgeranylacetone
oxidative stress
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Summary:Long-term administration of morphine for the management of chronic pain will result in tolerance to its analgesic effect and could even cause drug dependence. Numerous studies have demonstrated significant redox alteration in morphine dependence and addiction. Thioredoxin-1 (Trx-1) play important roles in controlling the cellular redox balance. In recent years, several recent studies have demonstrated that Trx-1 may be a promising novel therapeutic target for morphine addiction. In this article, we firstly review the redox alteration in morphine addiction. We also summarize the expression and the protective roles of Trx-1 in morphine dependence. We further highlight the protection of geranylgeranylacetone (GGA), a noncytotoxic pharmacological inducer of Trx-1, in morphine-induced conditioned place preference. In conclusion, Trx-1 may be very promising for clinical therapy of morphine addiction in the future.
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This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology
Edited by: Juan J. Canales, University of Tasmania, Australia
Reviewed by: Cristina Núñez, University of Murcia, Spain; Katia Gysling, Pontifical Catholic University of Chile, Chile
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2020.00082