Solute Carrier Family 30 Member 8 Gene 807C/T Polymorphism and Type 2 Diabetes Mellitus in the Chinese Population: A Meta-Analysis Including 6,942 Subjects

• Published in: Frontiers in endocrinology (Lausanne) Vol. 9; p. 263
• Main Authors: Li, Yan-Yan, Lu, Xin-Zheng, Wang, Hui, Yang, Xin-Xing, Geng, Hong-Yu, Gong, Ge, Zhan, Yi-Yang, Kim, Hyun Jun, Yang, Zhi-Jian
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 23.05.2018
• Subjects: 807C/T; Chinese; Endocrinology; polymorphism; solute carrier family 30 (zinc transporter) member 8; type 2 diabetes mellitus; solute carrier family 30 (zinc transporter) member 8; type 2 diabetes mellitus; Chinese; polymorphism; 807C/T
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2018.00263

Although gene 807C/T polymorphism is associated with an increased risk of type 2 diabetes mellitus (T2DM) risk, there remains some inconsistency between individual studies. The aim of the study is to explore the relationship between gene 807C/T polymorphism and T2DM in the Chinese population. The current meta-analysis compiles and analyzes the data of 6,942 participants from 10 independent studies. Either a fixed or random-effects model was adopted to evaluate the pooled odds ratio (ORs) and the corresponding 95% confidence interval (95% CI). A significant association between gene 807C/T polymorphism and T2DM was found in the Chinese population under allelic (OR: 0.85, 95% CI: 0.80-0.91,  = 7.42 × 10 ), recessive (OR: 0.52, 95% CI: 0.38-0.72,  = 8.49 × 10 ), dominant (OR: 2.40, 95% CI: 1.68-3.41,  = 1.30 × 10 ), homozygous (OR: 0.52, 95% CI: 0.40-0.67,  = 2.90 × 10 ), heterozygous (OR: 0.79, 95% CI: 0.71-0.88,  = 1.63 × 10 ), and additive genetic models (OR: 0.73, 95% CI: 0.64-0.83,  = 7.05 × 10 ). gene 807C/T polymorphism was significantly associated with an increased T2DM risk in the Chinese population. Therefore, individuals of Chinese descent with the C allele of gene 807C/T polymorphism may be more susceptible to developing T2DM, while individuals with the T allele may be protected against T2DM.