A Plasmodium Cross-Stage Antigen Contributes to the Development of Experimental Cerebral Malaria
Cerebral malaria is a complex neurological syndrome caused by an infection with parasites and is exclusively attributed to a series of host-parasite interactions at the pathological blood-stage of infection. In contrast, the preceding intra-hepatic phase of replication is generally considered clinic...
Saved in:
Published in | Frontiers in immunology Vol. 9; p. 1875 |
---|---|
Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
14.08.2018
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Cerebral malaria is a complex neurological syndrome caused by an infection with
parasites and is exclusively attributed to a series of host-parasite interactions at the pathological blood-stage of infection. In contrast, the preceding intra-hepatic phase of replication is generally considered clinically silent and thereby excluded from playing any role in the development of neurological symptoms. In this study, however, we present an antigen
maLS_05 that is presented to the host immune system by both pre-erythrocytic and intra-erythrocytic stages and contributes to the development of cerebral malaria in mice. Although deletion of the endogenous
maLS_05 prevented the development of experimental cerebral malaria (ECM) in susceptible mice after both sporozoite and infected red blood cell (iRBC) infections, we observed significant differences in contribution of the host immune response between both modes of inoculation. Moreover,
maLS_05-specific CD8
T cells contributed to the development of ECM after sporozoite but not iRBC-infection, suggesting that pre-erythrocytic antigens like
maLS_05 can also contribute to the development of cerebral symptoms. Our data thus highlight the importance of the natural route of infection in the study of ECM, with potential implications for vaccine and therapeutic strategies against malaria. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Ken J. Ishii, National Institutes of Biomedical Innovation, Health and Nutrition, Japan Present address: Priyanka Fernandes, CIMI-Paris, Inserm U1135, Faculté de Médecine Pierre et Marie Curie, Paris, France Reviewed by: Thomas Jacobs, Bernhard-Nocht-Institut für Tropenmedizin (BMITM), Germany; Giampietro Corradin, Université de Lausanne, Switzerland Specialty section: This article was submitted to Microbial Immunology, a section of the journal Frontiers in Immunology |
ISSN: | 1664-3224 1664-3224 |
DOI: | 10.3389/fimmu.2018.01875 |