Pharmacokinetics of Esomeprazole in Critically Ill Patients
Esomeprazole, a potent proton pump inhibitor (PPI), is widely used for the prevention of stress ulcers in intensive care unit (ICU) patients. This study investigates the pharmacokinetics (PK) of esomeprazole in critically ill patients. The study included eligible adult ICU patients who received endo...
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Published in | Frontiers in medicine Vol. 8; p. 621406 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
07.02.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Esomeprazole, a potent proton pump inhibitor (PPI), is widely used for the prevention of stress ulcers in intensive care unit (ICU) patients.
This study investigates the pharmacokinetics (PK) of esomeprazole in critically ill patients.
The study included eligible adult ICU patients who received endotracheal intubation assisted mechanical ventilation for more than 48 h and had at least an extra risk factor for stress ulcers. All enrolled patients received once-daily intravenous (IV) esomeprazole 40 mg. After the first dose of esomeprazole was administrated, serial blood samples were collected at 3, 5, 15, 30 min and 1, 2, 4, 6, 8, and 10 h. The total sample concentrations of esomeprazole were measured by UPLC-MS/MS. Esomeprazole PK parameters were analyzed using noncompartmental analysis.
A total of 30 patients were evaluable. Mean age and body mass index (BMI) were 61.97 years and 23.14. PK sampling on the first dose resulted in the following median (IQR) parameters: AUC
8.06 (6.65-9.47) mg·h/L; MRT
4.70 (3.89-5.51) h; t
3.29 (2.7-3.87) h; V 24.89 (22.09-27.69) L; CL 6.13 (5.01-7.26) L/h; and C
2.56 (2.30-2.82) mg/L.
According to the label of esomeprazole, our study showed different esomeprazole PK parameters in ICU patients compared with healthy volunteers. Esomeprazole has unique pharmacokinetic parameters in critically ill patients. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Mitsushige Sugimoto, Tokyo Medical University Hospital, Japan; Satish Kumar Bedada, Sanofi India Limited, India; Qian Zhao, Peking Union Medical College Hospital (CAMS), China Edited by: Chih-Hsien Wang, National Taiwan University Hospital, Taiwan These authors have contributed equally to this work This article was submitted to Intensive Care Medicine and Anesthesiology, a section of the journal Frontiers in Medicine |
ISSN: | 2296-858X 2296-858X |
DOI: | 10.3389/fmed.2021.621406 |