Vitamin D status and asthma, lung function, and hospitalization among British adults

• Published in: Frontiers in nutrition (Lausanne) Vol. 9; p. 954768
• Main Authors: Zhu, Yiqun, Jing, Danrong, Liang, Huaying, Li, Dianwu, Chang, Qinyu, Shen, Minxue, Pan, Pinhua, Liu, Hong, Zhang, Yan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 10.08.2022
• Subjects: asthma; lung functions; Nutrition; UK Biobank; vitamin D; wheeze; asthma; lung functions; wheeze; UK Biobank; vitamin D
• ISSN: 2296-861X; 2296-861X
• DOI: 10.3389/fnut.2022.954768

Vitamin D has been known to be associated with asthma. However, the association between vitamin D status and asthma, lung function as well as hospitalization among adults remains unclear. To investigate the role of serum vitamin D in asthma prevalence, lung function, and asthma control in adults. Multivariable logistic regression was applied to assess the relationship between serum vitamin D and asthma prevalence, lung function (FEV1, FVC, and FEV1/FVC), current wheeze, and asthma-linked hospitalizations in a cross-sectional study of 435,040 adults aged 37-73 years old from the UK Biobank. Compared to vitamin D deficiency, the odds of asthma were decreased by 6.4% [adjusted odds ratio ( ) = 0.936; 95% : 0.911-0.962; < 0.001] and 9.8% ( = 0. 0.902; 95% : 0.877-0. 0.927; < 0.001) in individuals with insufficient and optimal vitamin D concentration, respectively, in the fully adjusted model. In total asthmatic patients, serum vitamin D was obviously and positively related with FEV1 (β = 1.328 ml, 95% = 0.575-2.080), FVC (β = 2.018 ml, 95% = 1.127-2.908), and FEV1/FVC (β = 0.006%, 95% = 0.002-0.010). Asthmatic patients whose vitamin D level was in the deficient category had 9.3-19.9% higher odds of current wheeze than insufficient categories ( = 0.907; 95% : 0.861-0.957; < 0.001) and optimal categories ( = 0.801; 95% : 0.759-0.845; < 0.001), but the relationship between vitamin D and asthma hospitalization was not significant. Vitamin D deficiency was related to higher odds of asthma and current wheeze, and lower lung function in a large sample size study of British adults. Our results indicate a potential positive impact of serum vitamin D on asthma occurrence and disease control in adults.