Undifferentiated Pancreatic Carcinoma With Osteoclast-Like Giant Cells: What Do We Know So Far?
Undifferentiated carcinoma of the pancreas is an aggressive but rare tumor for which several other terms have been used to describe its histological appearance. In addition, as osteoclast-like giant cells may accompany undifferentiated carcinoma of the pancreas, the WHO Classification distinguishes...
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Published in | Frontiers in oncology Vol. 11; p. 630086 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
05.03.2021
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Subjects | |
Online Access | Get full text |
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Summary: | Undifferentiated carcinoma of the pancreas is an aggressive but rare tumor for which several other terms have been used to describe its histological appearance. In addition, as osteoclast-like giant cells may accompany undifferentiated carcinoma of the pancreas, the WHO Classification distinguishes undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) from plain undifferentiated carcinoma since there are a few histopathological and clinical differences. UC-OGC was initially thought to be associated with worse prognosis compared to invasive ductal pancreatic adenocarcinoma, since it is often unresectable at diagnosis and tends to recur rapidly even if completely resected. When true UC-OGGs are carefully dissected out from other anaplastic carcinomas, it becomes, however, clear that UC-OGCs do have more indolent behavior, especially the pure UC-OGCs. This mini-review summarizes the current knowledge on UC-OGC. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ORCID: Pieter Demetter orcid.org/0000-0001-7981-4645; Raphaël Maréchal orcid.org/0000-0002-1694-487X; Francesco Puleo orcid.org/0000-0003-2366-8073; Myriam Delhaye orcid.org/0000-0002-5456-8051; Sébastien Debroux orcid.org/0000-0002-4101-1203; Fadi Charara orcid.org/0000-0003-0277-8257; Maria Gomez Galdon orcid.org/0000-0001-6943-0402; Jean-Luc Van Laethem orcid.org/0000-0002-0785-0580; Laurine Verset orcid.org/0000-0002-4852-4386 Reviewed by: Jorg Kleeff, Martin Luther University of Halle-Wittenberg, Germany; Jin He, Johns Hopkins University, United States Edited by: Yun Dai, Peking University First Hospital, China This article was submitted to Gastrointestinal Cancers, a section of the journal Frontiers in Oncology |
ISSN: | 2234-943X 2234-943X |
DOI: | 10.3389/fonc.2021.630086 |