Antimicrobial aptamers for detection and inhibition of microbial pathogen growth

Discovery of alternative sources of antimicrobial agents are essential in the ongoing battle against microbial pathogens. Legislative and scientific challenges considerably hinder the discovery and use of new antimicrobial drugs, and new approaches are in urgent demand. On the other hand, rapid, spe...

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Bibliographic Details
Published inFuture microbiology Vol. 8; no. 3; pp. 387 - 401
Main Authors Özalp, Veli Cengiz, Bilecen, Kivanc, Kavruk, Murat, Avni Öktem, Hüseyin
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.03.2013
Subjects
Anti-Infective Agents - therapeutic use
Antibiotics
Antimicrobial agents
aptamers
Aptamers, Nucleotide - therapeutic use
Bacteria - drug effects
Bacteria - isolation & purification
biosensors
Communicable Diseases - drug therapy
Costs
Drugs
Forecasts and trends
Genomes
hygiene monitoring
Influenza
Ligands
Methods
Microbiological Techniques - methods
Microbiology
Microorganisms
multidrug resistance
pathogens
Peptide aptamers
Pharmacology, Experimental
Properties
Proteins
riboswitches
Staphylococcus infections
Structure-activity relationship (Pharmacology)
Structure-activity relationships
Technological change
Viruses - drug effects
Viruses - isolation & purification
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Summary:Discovery of alternative sources of antimicrobial agents are essential in the ongoing battle against microbial pathogens. Legislative and scientific challenges considerably hinder the discovery and use of new antimicrobial drugs, and new approaches are in urgent demand. On the other hand, rapid, specific and sensitive detection of airborne pathogens is becoming increasingly critical for public health. In this respect affinity oligonucleotides, aptamers, provide unique opportunities for the development of nanotechnological solutions for such medical applications. In recent years, aptamers specifically recognizing microbial cells and viruses showed great potential in a range of analytical and therapeutic applications. This article describes the significant advances in the development of aptamers targeting specific pathogens. Therapeutic application of aptamers as neutralizing agents demonstrates great potential as a future source of antimicrobial agent.
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ISSN:1746-0913
1746-0921
DOI:10.2217/fmb.12.149