Analysis of loss of heterozygosity in neoplastic nodules induced by diethylnitrosamine in the resistant BFF1 rat strain

• Published in: Carcinogenesis (New York) Vol. 20; no. 7; pp. 1363 - 1368
• Main Authors: Gariboldi, Manuela, Pascale, Rosa, Manenti, Giacomo, Miglio, Maria R.De, Calvisi, Diego, Carru, Angelo, Dragani, Tommaso A., Feo, Francesco
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.07.1999; Oxford Publishing Limited (England)
• Subjects: (BN×F344)F1 hybrid; 2-Acetylaminofluorene; Animals; BFF1; Biological and medical sciences; Brown Norway; Carcinogenesis, carcinogens and anticarcinogens; Carcinoma, Hepatocellular - chemically induced; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Chemical agents; Chromosome Mapping; Diethylnitrosamine; F344; Fisher 344; Genetic Markers; GST-P; HCC; hepatocellular carcinoma; Liver - drug effects; Liver - pathology; Liver Neoplasms - chemically induced; Liver Neoplasms - genetics; Liver Neoplasms - pathology; LOH; loss of heterozygosity; Loss of Heterozygosity - genetics; Male; Medical sciences; Microsatellite Repeats - genetics; placental glutathione S-transferase; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Rats; Rats, Inbred BN; Rats, Inbred F344; single sequence length polymorphism; SSLP; Tumors; Rat; Liver; Tumoral tissue; Rodentia; Hepatic disease; Malignant tumor; Resistance; Carcinogen; Vertebrata; Mammalia; Animal; Microsatellite DNA; Loss of heterozygosity; Digestive diseases; Genetics; Locus

Loss of heterozygosity (LOH) at specific chromosomal regions is a frequent event in poorly differentiated human hepatocellular carcinomas (HCCs), but rare in mouse HCCs. This behavior could depend on interspecies differences in mechanisms of hepatocarcinogenesis or in developmental stage of lesions....