Untangling a Web: Basic Mechanisms of the Complex Interactions Between Sleep, Circadian Rhythms, and Epilepsy

Seizures have sleep–wake and circadian patterns in various epilepsies and, in turn, disrupt sleep and circadian rhythms. The resultant sleep deprivation (SD) is an exacerbating factor for seizures that sets up a vicious cycle that can potentially lead to disease progression and even to epilepsy-rela...

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Bibliographic Details
Published inEpilepsy Currents Vol. 21; no. 2; pp. 105 - 110
Main Authors Maganti, Rama K., Jones, Mathew V.
Format Book Review Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.03.2021
Sage Publications Ltd
Subjects
Circadian rhythms
Convulsions & seizures
Current Review in Basic Science
Epilepsy
Mortality
Seizures
Sleep and wakefulness
Sleep deprivation
Transcription factors
epilepsy
sleep and circadian
seizures
neuronal excitability
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Summary:Seizures have sleep–wake and circadian patterns in various epilepsies and, in turn, disrupt sleep and circadian rhythms. The resultant sleep deprivation (SD) is an exacerbating factor for seizures that sets up a vicious cycle that can potentially lead to disease progression and even to epilepsy-related mortality. A variety of cellular or network electrophysiological changes and changes in expression of clock-controlled genes or other transcription factors underlie sleep–wake and circadian distribution of seizures, as well as the disruptions seen in both. A broad understanding of these mechanisms may help in designing better treatments to prevent SD-induced seizure exacerbation, disrupt the vicious cycle of disease progression, and reduce epilepsy-related mortality.
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ISSN:1535-7597
1535-7511
DOI:10.1177/1535759721989674