Obesity and Brain Function: The Brain–Body Crosstalk

• Published in: Medicina (Kaunas, Lithuania) Vol. 56; no. 10; p. 499
• Main Authors: Sui, Sophia X., Pasco, Julie A.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 24.09.2020; MDPI AG
• Subjects: BDNF; Brain; brain function; Central Nervous System; cognitive function; Humans; inflammation; leptin; obesity; Obesity - complications; Review; cognitive function; brain function; BDNF; inflammation; leptin; obesity
• ISSN: 1648-9144; 1010-660X; 1648-9144
• DOI: 10.3390/medicina56100499

Dementia comprises a wide range of progressive and acquired neurocognitive disorders. Obesity, defined as excessive body fat tissue, is a common health issue world-wide and a risk factor for dementia. The adverse effects of obesity on the brain and the central nervous system have been the subject of considerable research. The aim of this review is to explore the available evidence in the field of body–brain crosstalk focusing on obesity and brain function, to identify the major research measurements and methodologies used in the field, to discuss the potential risk factors and biological mechanisms, and to identify the research gap as a precursor to systematic reviews and empirical studies in more focused topics related to the obesity–brain relationship. To conclude, obesity appears to be associated with reduced brain function. However, obesity is a complex health condition, while the human brain is the most complicated organ, so research in this area is difficult. Inconsistency in definitions and measurement techniques detract from the literature on brain–body relationships. Advanced techniques developed in recent years are capable of improving investigations of this relationship.