The KCNE Tango - How KCNE1 Interacts with Kv7.1

The classical tango is a dance characterized by a 2/4 or 4/4 rhythm in which the partners dance in a coordinated way, allowing dynamic contact. There is a surprising similarity between the tango and how KCNE β-subunits "dance" to the fast rhythm of the cell with their partners from the Kv...

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Published inFrontiers in pharmacology Vol. 3; p. 142
Main Authors Wrobel, Eva, Tapken, Daniel, Seebohm, Guiscard
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 01.01.2012
Frontiers Media S.A
Subjects
beta-subunits
Gating
KCNE
Kv channels
Kv7.1
Pharmacology
Kv7.1
KCNE1
Kv channel
β-subunit
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Summary:The classical tango is a dance characterized by a 2/4 or 4/4 rhythm in which the partners dance in a coordinated way, allowing dynamic contact. There is a surprising similarity between the tango and how KCNE β-subunits "dance" to the fast rhythm of the cell with their partners from the Kv channel family. The five KCNE β-subunits interact with several members of the Kv channels, thereby modifying channel gating via the interaction of their single transmembrane-spanning segment, the extracellular amino terminus, and/or the intracellular carboxy terminus with the Kv α-subunit. Best studied is the molecular basis of interactions between KCNE1 and Kv7.1, which, together, supposedly form the native cardiac I(Ks) channel. Here we review the current knowledge about functional and molecular interactions of KCNE1 with Kv7.1 and try to summarize and interpret the tango of the KCNEs.
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Edited by: Gildas Loussouarn, University of Nantes, France
This article was submitted to Frontiers in Pharmacology of Ion Channels and Channelopathies, a specialty of Frontiers in Pharmacology.
Reviewed by: Robert Kass, Colombia University in the city of New York, USA; Tom V. McDonald, Albert Einstein College of Medicine, USA
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2012.00142