Mitochondrial Effects on Seeds of Cancer Survival in Leukemia

The cancer metabolic alteration is considered a hallmark and fast becoming a road for therapeutic intervention. Mitochondria have been regarded as essential cell elements that fuel the metabolic needs of most cancer cell types. Leukemia stem cells (LSCs) are a heterogeneous, highly self-renewing, an...

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Published inFrontiers in oncology Vol. 11; p. 745924
Main Authors El-Shaqanqery, Hend E, Mohamed, Rania Hassan, Sayed, Ahmed A
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 07.10.2021
Subjects
leukemia
leukemia stem cell
metabolism
mitochondria
mitophagy
Oncology
leukemia
leukemia stem cell
mitophagy
metabolism
mitochondria
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Summary:The cancer metabolic alteration is considered a hallmark and fast becoming a road for therapeutic intervention. Mitochondria have been regarded as essential cell elements that fuel the metabolic needs of most cancer cell types. Leukemia stem cells (LSCs) are a heterogeneous, highly self-renewing, and pluripotent cell population within leukemic cells. The most important source of ATP and metabolites to fulfill the bioenergetics and biosynthetic needs of most cancer stem cells is the mitochondria. In addition, mitochondria have a core role in autophagy and cell death and are the main source of reactive oxygen species (ROS) generation. Overall, growing evidence now shows that mitochondrial activities and pathways have changed to adapt with different types of leukemia, thus mitochondrial metabolism could be targeted for blood malignancy therapy. This review focuses on the function of mitochondria in LSC of the different leukemia types.
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This article was submitted to Cancer Metabolism, a section of the journal Frontiers in Oncology
Edited by: Michael P. Lisanti, University of Salford Manchester, United Kingdom
Reviewed by: Pritam Sadhukhan, Johns Hopkins University, United States; Cinzia Domenicotti, Università di Genova, Italy
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.745924