Association Between 12 Polymorphisms of VEGF/Hypoxia/Angiogenesis Pathway Genes and Risk of Urogenital Carcinomas: A Meta-Analysis Based on Case-Control Studies

• Published in: Frontiers in physiology Vol. 9; p. 715
• Main Authors: Chen, Jin-Bo, Zhang, Meng, Cui, Yu, Liu, Pei-Hua, Qi, Yan-Wei, Li, Chao, Cheng, Xu, Ren, Wen-Biao, Li, Qia-Qia, Liu, Long-Fei, Chen, Min-Feng, Chen, He-Qun, Zu, Xiong-Bing
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 11.06.2018
• Subjects: meta-analysis; Physiology; polymorphism; susceptibility; urogenital carcinomas; VEGF/hypoxia/angiogenesis; meta-analysis; VEGF/hypoxia/angiogenesis; polymorphism; susceptibility; urogenital carcinomas
• ISSN: 1664-042X; 1664-042X
• DOI: 10.3389/fphys.2018.00715

Previous studies indicated potential associations between polymorphisms in genes of VEGF/hypoxia/angiogenesis pathway and risk of urogenital carcinomas However, the results were controversial and inconclusive. Here, we conducted an in-depth meta-analysis to investigate the precise associations between polymorphisms in VEGF/hypoxia/angiogenesis related genes and risk of urogenital carcinomas. We searched PubMed, Web of Science, EMBASE, and Cochrane Library to identify all eligible publications. Pooled odds ratios (ORs) corresponding with the 95% confidence intervals (CIs) were calculated to evaluate their associations. Subgroup analysis was conducted to further ascertain such relationship and investigate sources of heterogeneity. In the end, a total of 96 case-control studies fulfilled the inclusion criteria were enrolled for 12 polymorphisms in 4 VEGF/hypoxia/angiogenesis related genes. The pooled results showed eNOS-rs2070744 polymorphism conferred a significantly increased overall risk of urogenital carcinomas in allele, homozygote, and recessive models, respectively. In addition, eNOS-Intron 4a/b VNTR polymorphism was identified related to an increased risk of urogenital carcinomas in recessive model. And VEGF-rs699947 polymorphism was also identified an increased risk of renal cell carcinoma (RCC) in allelic, heterozygote, dominant, homozygote, and recessive models. To conclude, eNOS-rs2070744 and eNOS-Intron 4a/b VNTR polymorphisms are risk factors for urogenital carcinomas. VEGF-rs699947 polymorphism was also identified as an increased risk factor for renal carcinoma.