Gastric Schwannomas show an obviously increased fluorodeoxyglucose uptake in positron emission tomography: Report of two cases

Schwannomas are tumors originating from any nerve that has a Schwann cell sheath. Gastrointestinal (GI) schwannomas represent only 3% of all GI mesenchymal tumors. The stomach is the most common site of GI schwannomas, and schwannomas account for 0.2% of all gastric neoplasms. This report presents t...

Full description

Saved in:
Bibliographic Details
Published inSurgery today (Tokyo, Japan) Vol. 41; no. 8; pp. 1133 - 1137
Main Authors Ohno, Tetsuro, Ogata, Kyoichi, Kogure, Norimichi, Ando, Hiroyuki, Aihara, Ryuusuke, Mochiki, Erito, Zai, Hiroaki, Sano, Akihiko, Kato, Toshihide, Sakurai, Shinji, Oyama, Tetsunari, Asao, Takayuki, Kuwano, Hiroyuki
Format Journal Article
LanguageEnglish
Published Japan Springer Japan 01.08.2011
Subjects
Aged
Case Report
Female
Fluorodeoxyglucose F18 - pharmacokinetics
Humans
Medicine
Medicine & Public Health
Middle Aged
Neurilemmoma - diagnostic imaging
Neurilemmoma - metabolism
Positron-Emission Tomography
Radiopharmaceuticals - pharmacokinetics
Stomach Neoplasms - diagnostic imaging
Stomach Neoplasms - metabolism
Surgery
Surgical Oncology
Stomach
Glucose transporter type 1
Autocrine motility factor
Submucosal tumor
Schwannoma
Online AccessGet full text

Cover

More Information
Summary:Schwannomas are tumors originating from any nerve that has a Schwann cell sheath. Gastrointestinal (GI) schwannomas represent only 3% of all GI mesenchymal tumors. The stomach is the most common site of GI schwannomas, and schwannomas account for 0.2% of all gastric neoplasms. This report presents two cases of gastric schwannomas showing increased [18F]fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET; maximum standardized uptake value 7.10 and 6.05). Additional immunohistochemical staining of glucose transporter type 1 (GLUT1) and the autocrine motility factor (AMF) was conducted after the tumors were resected, to identify the mechanism that increased FDG uptake on PET. Immunohistochemical expression of AMF was positive in both cases, whereas GLUT1 was negative. Autocrine motility factor is also known as phosphoglucose isomerase. However, the mechanism by which FDG is accumulated in schwannoma cells is uncertain, and may be related to intracellular glycolytic activity.
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-010-4401-2