Dendritic Cells and T Cells, Partners in Atherogenesis and the Translating Road Ahead

Atherosclerosis is a chronic process associated with arterial inflammation, the accumulation of lipids, plaque formation in vessel walls, and thrombosis with late mortal complications such as myocardial infarction and ischemic stroke. Immune and inflammatory responses have significant effects on eve...

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Published inFrontiers in immunology Vol. 11; p. 1456
Main Authors Sun, Li, Zhang, Wenjie, Zhao, Yanfang, Wang, Fengge, Liu, Shan, Liu, Lei, Zhao, Lin, Lu, Wei, Li, Minghui, Xu, Yuekang
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 29.07.2020
Subjects
Animals
atherosclerosis
Atherosclerosis - immunology
Cellular Microenvironment
dendritic cells
Dendritic Cells - immunology
Humans
Immunology
immunotherapy
Immunotherapy - methods
inflammation
T cells
T-Lymphocytes - immunology
Translational Medical Research
atherosclerosis
dendritic cells
T cells
inflammation
immunotherapy
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Summary:Atherosclerosis is a chronic process associated with arterial inflammation, the accumulation of lipids, plaque formation in vessel walls, and thrombosis with late mortal complications such as myocardial infarction and ischemic stroke. Immune and inflammatory responses have significant effects on every phase of atherosclerosis. Increasing evidence has shown that both innate and adaptive "arms" of the immune system play important roles in regulating the progression of atherosclerosis. Accumulating evidence suggests that a unique type of innate immune cell, termed dendritic cells (DCs), play an important role as central instigators, whereas adaptive immune cells, called T lymphocytes, are crucial as active executors of the DC immunity in atherogenesis. These two important immune cell types work in pairs to establish pro-atherogenic or atheroprotective immune responses in vascular tissues. Therefore, understanding the role of DCs and T cells in atherosclerosis is extremely important. Here, in this review, we will present a complete overview, based on existing knowledge of these two cell types in the atherosclerotic microenvironment, and discuss some of the novel means of targeting DCs and T cells as therapeutic tactics for the treatment of atherosclerosis.
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This article was submitted to Antigen Presenting Cell Biology, a section of the journal Frontiers in Immunology
Reviewed by: Maliheh Nazari-Jahantigh, Ludwig Maximilian University of Munich, Germany; Yvonne Döring, Ludwig Maximilian University of Munich, Germany
Edited by: Laura Santambrogio, Cornell University, United States
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2020.01456