Genital Micro-Organisms in Pregnancy

The microbiome of the female genital tract may undergo changes in pregnancy due to metabolic, endocrinological, and immunological alterations. These dysbiotic states may cause infections which may ascend upwards to the feto-placental unit or may be seeded hematogenously. These low grade and often lo...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in public health Vol. 8; p. 225
Main Authors Bagga, Rashmi, Arora, Parul
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 16.06.2020
Subjects
bacterial vaginosis
candidiasis
Candidiasis, Vulvovaginal
Dysbiosis
Female
genital microbiome
Humans
Pregnancy
Pregnancy Complications, Infectious
Prevalence
Public Health
Trichomonas vaginalis
Trichomonas Vaginitis
Vaginosis, Bacterial - diagnosis
Trichomonas vaginalis
candidiasis
bacterial vaginosis
genital microbiome
dysbiosis
Online AccessGet full text

Cover

More Information
Summary:The microbiome of the female genital tract may undergo changes in pregnancy due to metabolic, endocrinological, and immunological alterations. These dysbiotic states may cause infections which may ascend upwards to the feto-placental unit or may be seeded hematogenously. These low grade and often low virulent infectious states lead to chronic inflammatory states and maybe associated with adverse maternal and neonatal outcome. Organisms have been isolated from amniotic fluid and placentae from women delivering pre-term; however the possibility of contamination cannot be conclusively ruled out. Common vaginal dysbiotic states often cause symptoms that are overlooked and often untreated. Vulvovaginal Candidiasis (VVC), Bacterial Vaginosis (BV), and Trichomonas Vaginitis (TV) are the commonly occurring dysbiotic states leading to vaginal infective states in pregnancy. With the advent of novel technologies like Next Generation sequencing (NGS), it will soon be possible to comprehensively map the vaginal microbiome and assess the interplay of each microbial state with their effects in pregnancy. This may open new avenues for antibiotic recommendations, probiotics and potential alternate therapies for dysbiotic states leading to pregnancy complications.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Edited by: Elena Ambrosino, Maastricht University, Netherlands
This article was submitted to Infectious Diseases - Surveillance, Prevention and Treatment, a section of the journal Frontiers in Public Health
Reviewed by: Phileno Pinge-Filho, State University of Londrina, Brazil; Tingtao Chen, Nanchang University, China; Barbra Richardson, University of Washington, United States
ISSN:2296-2565
2296-2565
DOI:10.3389/fpubh.2020.00225