Processing of Degraded Speech in Brain Disorders

• Published in: Brain sciences Vol. 11; no. 3; p. 394
• Main Authors: Jiang, Jessica, Benhamou, Elia, Waters, Sheena, Johnson, Jeremy C S, Volkmer, Anna, Weil, Rimona S, Marshall, Charles R, Warren, Jason D, Hardy, Chris J D
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 20.03.2021; MDPI AG
• Subjects: Alzheimer’s disease; degraded speech processing; Parkinson’s disease; perceptual learning; predictive coding; primary progressive aphasia; Review; Alzheimer’s disease; perceptual learning; predictive coding; dementia; Parkinson’s disease; degraded speech processing; primary progressive aphasia
• ISSN: 2076-3425; 2076-3425
• DOI: 10.3390/brainsci11030394

The speech we hear every day is typically "degraded" by competing sounds and the idiosyncratic vocal characteristics of individual speakers. While the comprehension of "degraded" speech is normally automatic, it depends on dynamic and adaptive processing across distributed neural networks. This presents the brain with an immense computational challenge, making degraded speech processing vulnerable to a range of brain disorders. Therefore, it is likely to be a sensitive marker of neural circuit dysfunction and an index of retained neural plasticity. Considering experimental methods for studying degraded speech and factors that affect its processing in healthy individuals, we review the evidence for altered degraded speech processing in major neurodegenerative diseases, traumatic brain injury and stroke. We develop a predictive coding framework for understanding deficits of degraded speech processing in these disorders, focussing on the "language-led dementias"-the primary progressive aphasias. We conclude by considering prospects for using degraded speech as a probe of language network pathophysiology, a diagnostic tool and a target for therapeutic intervention.