How to B(e)-1 Important Cell During Leishmania Infection

B-1 cells are an innate-like population of B lymphocytes that are subdivided into B-1a and B-1b distinguished by the presence or absence of CD5, respectively. B-1 cells can act as regulatory B cells, are able to present antigen and produce IL-10. Leishmaniasis in humans is a complex of diseases caus...

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Published inFrontiers in cellular and infection microbiology Vol. 9; p. 424
Main Authors Firmino-Cruz, Luan, Decote-Ricardo, Debora, Gomes, Daniel Claudio de Oliveira, Morrot, Alexandre, Freire-de-Lima, Celio Geraldo, de Matos Guedes, Herbert Leonel
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 14.01.2020
Subjects
B-1 cells
B-1CDP cells
BALB/XID
Cellular and Infection Microbiology
IL-10
Leishmaniasis
BALB/XID
Leishmaniasis
B-1CDP cells
IL-10
B-1 cells
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Abstract B-1 cells are an innate-like population of B lymphocytes that are subdivided into B-1a and B-1b distinguished by the presence or absence of CD5, respectively. B-1 cells can act as regulatory B cells, are able to present antigen and produce IL-10. Leishmaniasis in humans is a complex of diseases caused by parasites of the genus . More than 20 species can infect humans, with each species causing the development of different immunological responses in the host. Susceptibility is usually related to the production of anti-inflammatory cytokines while the production of Th1 cytokines is indicative of resistance. However, few studies have attempted to evaluate the role of B-1 cells during either the infection or interaction with parasites. studies were performed using XID mice model, BALB/Xid mice have a mutation in the Bruton's tyrosine kinase, which is an important enzyme for developing B-1 and maturing B-2 lymphocytes leading to the presence of immature B-2 cells. Here, we compile these studies and assess the influence of B-1 cells on disease progression with different species.
AbstractList B-1 cells are an innate-like population of B lymphocytes that are subdivided into B-1a and B-1b distinguished by the presence or absence of CD5, respectively. B-1 cells can act as regulatory B cells, are able to present antigen and produce IL-10. Leishmaniasis in humans is a complex of diseases caused by parasites of the genus . More than 20 species can infect humans, with each species causing the development of different immunological responses in the host. Susceptibility is usually related to the production of anti-inflammatory cytokines while the production of Th1 cytokines is indicative of resistance. However, few studies have attempted to evaluate the role of B-1 cells during either the infection or interaction with parasites. studies were performed using XID mice model, BALB/Xid mice have a mutation in the Bruton's tyrosine kinase, which is an important enzyme for developing B-1 and maturing B-2 lymphocytes leading to the presence of immature B-2 cells. Here, we compile these studies and assess the influence of B-1 cells on disease progression with different species.
B-1 cells are an innate-like population of B lymphocytes that are subdivided into B-1a and B-1b distinguished by the presence or absence of CD5, respectively. B-1 cells can act as regulatory B cells, are able to present antigen and produce IL-10. Leishmaniasis in humans is a complex of diseases caused by parasites of the genus Leishmania. More than 20 species can infect humans, with each species causing the development of different immunological responses in the host. Susceptibility is usually related to the production of anti-inflammatory cytokines while the production of Th1 cytokines is indicative of resistance. However, few studies have attempted to evaluate the role of B-1 cells during either the in vivo infection or in vitro interaction with Leishmania parasites. In vivo studies were performed using XID mice model, BALB/Xid mice have a mutation in the Bruton's tyrosine kinase, which is an important enzyme for developing B-1 and maturing B-2 lymphocytes leading to the presence of immature B-2 cells. Here, we compile these studies and assess the influence of B-1 cells on disease progression with different Leishmania species.
B-1 cells are an innate-like population of B lymphocytes that are subdivided into B-1a and B-1b distinguished by the presence or absence of CD5, respectively. B-1 cells can act as regulatory B cells, are able to present antigen and produce IL-10. Leishmaniasis in humans is a complex of diseases caused by parasites of the genus Leishmania . More than 20 species can infect humans, with each species causing the development of different immunological responses in the host. Susceptibility is usually related to the production of anti-inflammatory cytokines while the production of Th1 cytokines is indicative of resistance. However, few studies have attempted to evaluate the role of B-1 cells during either the in vivo infection or in vitro interaction with Leishmania parasites. In vivo studies were performed using XID mice model, BALB/Xid mice have a mutation in the Bruton's tyrosine kinase, which is an important enzyme for developing B-1 and maturing B-2 lymphocytes leading to the presence of immature B-2 cells. Here, we compile these studies and assess the influence of B-1 cells on disease progression with different Leishmania species.
Author Firmino-Cruz, Luan
Morrot, Alexandre
de Matos Guedes, Herbert Leonel
Decote-Ricardo, Debora
Gomes, Daniel Claudio de Oliveira
Freire-de-Lima, Celio Geraldo
AuthorAffiliation 7 Laboratório de Imunomodulação, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal Do Rio de Janeiro , Rio de Janeiro , Brazil
8 Núcleo Multidisciplinar de Pesquisa UFRJ—Xerém em Biologia (NUMPEX-BIO), UFRJ Campus Duque de Caxias Professor Geraldo Cidade, Universidade Federal Do Rio de Janeiro , Duque de Caxias , Brazil
2 Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz , Rio de Janeiro , Brazil
5 Laboratório de Imunopatologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz , Rio de Janeiro , Brazil
4 Núcleo de Doenças Infecciosas/Núcleo de Biotecnologia, Universidade Federal Do Espírito Santo , Vitoria , Brazil
6 Faculdade de Medicina, Universidade Federal Do Rio de Janeiro , Rio de Janeiro , Brazil
3 Instituto de Veterinária, Universidade Federal Rural Do Rio de Janeiro , Seropédica , Brazil
1 Laboratório de Imunofarmacologia, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal Do Rio de Janeiro , Rio de Janeiro , Br
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Copyright Copyright © 2020 Firmino-Cruz, Decote-Ricardo, Gomes, Morrot, Freire-de-Lima and de Matos Guedes.
Copyright © 2020 Firmino-Cruz, Decote-Ricardo, Gomes, Morrot, Freire-de-Lima and de Matos Guedes. 2020 Firmino-Cruz, Decote-Ricardo, Gomes, Morrot, Freire-de-Lima and de Matos Guedes
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Keywords BALB/XID
Leishmaniasis
B-1CDP cells
IL-10
B-1 cells
Language English
License Copyright © 2020 Firmino-Cruz, Decote-Ricardo, Gomes, Morrot, Freire-de-Lima and de Matos Guedes.
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This article was submitted to Parasite and Host, a section of the journal Frontiers in Cellular and Infection Microbiology
Reviewed by: Hira Nakhasi, Center for Biologics Evaluation and Research (FDA), United States; Salvador Iborra, Complutense University of Madrid, Spain; Angamuthu Selvapandiyan, Jamia Hamdard University, India
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SubjectTerms B-1 cells
B-1CDP cells
BALB/XID
Cellular and Infection Microbiology
IL-10
Leishmaniasis
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Title How to B(e)-1 Important Cell During Leishmania Infection
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