How to B(e)-1 Important Cell During Leishmania Infection

• Published in: Frontiers in cellular and infection microbiology Vol. 9; p. 424
• Main Authors: Firmino-Cruz, Luan, Decote-Ricardo, Debora, Gomes, Daniel Claudio de Oliveira, Morrot, Alexandre, Freire-de-Lima, Celio Geraldo, de Matos Guedes, Herbert Leonel
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14.01.2020
• Subjects: B-1 cells; B-1CDP cells; BALB/XID; Cellular and Infection Microbiology; IL-10; Leishmaniasis; BALB/XID; Leishmaniasis; B-1CDP cells; IL-10; B-1 cells
• ISSN: 2235-2988; 2235-2988
• DOI: 10.3389/fcimb.2019.00424

B-1 cells are an innate-like population of B lymphocytes that are subdivided into B-1a and B-1b distinguished by the presence or absence of CD5, respectively. B-1 cells can act as regulatory B cells, are able to present antigen and produce IL-10. Leishmaniasis in humans is a complex of diseases caused by parasites of the genus . More than 20 species can infect humans, with each species causing the development of different immunological responses in the host. Susceptibility is usually related to the production of anti-inflammatory cytokines while the production of Th1 cytokines is indicative of resistance. However, few studies have attempted to evaluate the role of B-1 cells during either the infection or interaction with parasites. studies were performed using XID mice model, BALB/Xid mice have a mutation in the Bruton's tyrosine kinase, which is an important enzyme for developing B-1 and maturing B-2 lymphocytes leading to the presence of immature B-2 cells. Here, we compile these studies and assess the influence of B-1 cells on disease progression with different species.