Correlation between dynamic susceptibility contrast perfusion MRI and methionine metabolism in brain gliomas: Preliminary results

• Published in: Journal of magnetic resonance imaging Vol. 24; no. 5; pp. 989 - 994
• Main Authors: Sadeghi, Niloufar, Salmon, Isabelle, Tang, Bich Ngoc Thanh, Denolin, Vincent, Levivier, Marc, Wikler, David, Rorive, Sandrine, Balériaux, Danielle, Metens, Thierry, Goldman, Serge
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2006
• Subjects: Adult; Aged; Brain Neoplasms - blood supply; Brain Neoplasms - diagnosis; Brain Neoplasms - metabolism; Cerebrovascular Circulation; Contrast Media; Female; Glioma - blood supply; Glioma - diagnosis; Glioma - metabolism; gliomas; Humans; magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Methionine - analogs & derivatives; Methionine - pharmacokinetics; Middle Aged; perfusion; PET imaging; Pilot Projects; Positron-Emission Tomography - methods; Radiopharmaceuticals - pharmacokinetics; Reproducibility of Results; Sensitivity and Specificity; Statistics as Topic
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/jmri.20757

Purpose To evaluate in brain gliomas the relationship between tumor vascularity measured by MR‐based maximum regional cerebral blood volume (rCBV) and tumor amino‐acid metabolism based on maximum carbon‐11 methionine (MET) uptake on positron emission tomography (PET). Materials and Methods Eighteen patients with histologically proven primary brain gliomas were included in the study. In addition to conventional MR sequences, dynamic MR images, including a first‐pass gadopentetate dimeglumine T2*‐weighted echo‐planar perfusion sequence and a PET study using MET, were acquired. Eleven patients had low‐grade gliomas, and seven had high‐grade gliomas. rCBV ratios and MET uptake ratios normalized to the contralateral white matter (WM) corresponding values were measured in each tumor. Both maximum rCBV ratios and maximum MET uptake ratios were correlated to histopathology. The maximum rCBV ratios were correlated to the maximum MET uptake ratios. Results Both the maximum rCBV ratios and maximum MET uptake ratios of high‐grade gliomas were significantly higher than those of low‐grade gliomas (P < 0.05). There was a significant positive correlation between maximum rCBV ratios and maximum MET uptake ratios (Spearman: r = 0.89, P < 0.00001). Conclusion The maximum rCBV ratio and maximum MET uptake ratio are significantly correlated in gliomas, reflecting a close link between amino acid uptake and vascularity in these tumors. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.