Prolonged oral antibiotic suppression in osteomyelitis and associated outcomes in a Veterans population

• Published in: American journal of health-system pharmacy Vol. 72; no. 23 Suppl 3; pp. S150 - S155
• Main Authors: Nowak, Michael A, Winner, Jamie S, Beilke, Mark A
• Format: Journal Article
• Language: English
• Published: England Copyright American Society of Health-System Pharmacists, Inc. All rights reserved 01.12.2015; Oxford University Press
• Subjects: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - administration & dosage; Antibiotics; Dosage and administration; Drug Administration Schedule; Drug therapy; Female; Follow-Up Studies; Humans; Male; Middle Aged; Oral drugs; Osteomyelitis; Osteomyelitis - diagnosis; Osteomyelitis - drug therapy; Patient outcomes; Retrospective Studies; Treatment Outcome; Veterans; United States
• ISSN: 1079-2082; 1535-2900
• DOI: 10.2146/sp150022

OBJECTIVE.Prolonged oral antimicrobial suppression has been suggested as an alternative treatment for patients with prosthetic joint infections who are unable or unwilling to undergo surgical intervention; however, little data exists for utilizing this approach in patients with chronic osteomyelitis and no artificial hardware. METHODS.We retrospectively reviewed the medical records of all patients over a 5-year time frame who were treated with chronic oral antibiotic suppression for osteomyelitis and who had no artificial hardware. Clinical outcomes, risk factors for treatment failure, and adverse drug reactions were evaluated. RESULTS.A total of 20 patients were included for evaluation, of which 12 (60%) were able to achieve successful suppression of disease for a mean duration of 778 ± 408 days after discontinuation. Diabetic patients were found to be at higher risk for treatment failure (p = 0.0281). We also identified a high rate of adverse events (25%) attributable to suppressive medications. Despite elevated inflammatory markers contributing to the decision to initiate antibiotic suppression in the majority of patients, few were able to achieve normal values throughout suppressive therapy. CONCLUSION.Further randomized, controlled studies are needed to determine the utility of antibiotic suppression. However, prolonged oral antibiotic suppression may be a reasonable last-line treatment alternative for chronic osteomyelitis, even in the absence of artificial hardware, for patients who are unwilling or unable to undergo optimal surgical intervention.