Pharmacologic development of male hormonal contraceptive agents

The world population continues to increase dramatically despite the existence of contraceptive technology. The use of male hormonal contraception may help in preventing un intended pregnancies and managing future population growth. Male hormonal contraception relies on the administration of exogenou...

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Bibliographic Details
Published inClinical pharmacology and therapeutics Vol. 89; no. 1; p. 133
Main Authors Roth, M Y, Amory, J K
Format Journal Article
LanguageEnglish
Published United States 01.01.2011
Subjects
Animals
Contraceptive Agents, Male - adverse effects
Contraceptive Agents, Male - pharmacology
Contraceptive Agents, Male - therapeutic use
Drug Design
Drugs, Investigational - adverse effects
Drugs, Investigational - pharmacology
Drugs, Investigational - therapeutic use
Humans
Male
Spermatogenesis-Blocking Agents - adverse effects
Spermatogenesis-Blocking Agents - pharmacology
Spermatogenesis-Blocking Agents - therapeutic use
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Summary:The world population continues to increase dramatically despite the existence of contraceptive technology. The use of male hormonal contraception may help in preventing un intended pregnancies and managing future population growth. Male hormonal contraception relies on the administration of exogenous hormones to suppress spermatogenesis. Clinical trials have tested several regimens using testosterone, alone or in combination with a progestin. These regimens were shown to be >90% effective in preventing conception and were not associated with serious adverse events.
ISSN:1532-6535
DOI:10.1038/clpt.2010.103