Cats, Cancer and Comparative Oncology

Naturally occurring tumors in dogs are well-established models for several human cancers. Domestic cats share many of the benefits of dogs as a model (spontaneous cancers developing in an immunocompetent animal sharing the same environment as humans, shorter lifespan allowing more rapid trial comple...

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Published inVeterinary sciences Vol. 2; no. 3; pp. 111 - 126
Main Author Cannon, Claire M
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 30.06.2015
MDPI
Subjects
Animal models
Cancer therapies
Clinical trials
comparative oncology
Dogs
Drugs
Epidermal growth factor
feline cancer
Genomes
Head & neck cancer
Life span
Oncology
Oral squamous cell carcinoma
Phenotypes
Primary care
Review
Sarcoma
Squamous cell carcinoma
Tumorigenesis
Tumors
Veterinarians
Veterinary medicine
United States > US
feline cancer
animal models
comparative oncology
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Summary:Naturally occurring tumors in dogs are well-established models for several human cancers. Domestic cats share many of the benefits of dogs as a model (spontaneous cancers developing in an immunocompetent animal sharing the same environment as humans, shorter lifespan allowing more rapid trial completion and data collection, lack of standard of care for many cancers allowing evaluation of therapies in treatment-naïve populations), but have not been utilized to the same degree in the One Medicine approach to cancer. There are both challenges and opportunities in feline compared to canine models. This review will discuss three specific tumor types where cats may offer insights into human cancers. Feline oral squamous cell carcinoma is common, shares both clinical and molecular features with human head and neck cancer and is an attractive model for evaluating new therapies. Feline mammary tumors are usually malignant and aggressive, with the 'triple-negative' phenotype being more common than in humans, offering an enriched population in which to examine potential targets and treatments. Finally, although there is not an exact corollary in humans, feline injection site sarcoma may be a model for inflammation-driven tumorigenesis, offering opportunities for studying variations in individual susceptibility as well as preventative and therapeutic strategies.
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Current Address: University of Minnesota Veterinary Clinical Sciences Department, 1352 Boyd Ave, St Paul, MN 55108, USA.
ISSN:2306-7381
2306-7381
DOI:10.3390/vetsci2030111