Cutaneous sclerosing Pacinian-like perineurioma

• Published in: Histopathology Vol. 39; no. 5; pp. 498 - 502
• Main Authors: Burgues, O, Monteagudo, C, Noguera, R, Revert, A, Molina, I, Llombart-Bosch, A
• Format: Journal Article
• Language: English
• Published: Oxford UK Blackwell Science Ltd 01.11.2001; Blackwell
• Subjects: Adult; Biological and medical sciences; Chromosome Aberrations; Chromosomes, Human, Pair 22 - genetics; Dermatology; Female; FISH; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Medical sciences; Mucin-1 - analysis; Nerve Sheath Neoplasms - genetics; Nerve Sheath Neoplasms - metabolism; Nerve Sheath Neoplasms - pathology; nerve sheath tumour; Pacinian Corpuscles - pathology; perineurial cell; perineurioma; Sclerosis - pathology; Skin Neoplasms - genetics; Skin Neoplasms - metabolism; Skin Neoplasms - pathology; soft tissue; Tumors of the skin and soft tissue. Premalignant lesions; Vimentin - analysis; Human; Immunohistochemistry; Skin disease; Nervous system diseases; Cell differentiation; Sclerosis; Case study; Pathology; Perineurium; Pacini corpuscle; Fluorescence in situ hybridization; Adult; Female; Tumor; Skin; Molecular biology
• ISSN: 0309-0167; 1365-2559
• DOI: 10.1046/j.1365-2559.2001.01251.x

Cutaneous sclerosing Pacinian‐like perineurioma Aims: The term perineurioma has been used to designate a variety of clinically and histologically different proliferations of perineurial cells based on immunohistochemical and/or ultrastructural characterization. There are two different groups of neoplasms derived from perineurial cells: extraneural or soft tissue perineuriomas, and intraneural perineuriomas. Recently, a sclerosing variant of cutaneous perineurioma has been described. Methods and results: We report a case of a cutaneous form of perineurioma, combining features of the intraneural and sclerosing varieties, as well as showing a Pacinian pattern of growth. In order to assess the neoplastic nature of the lesion, we performed fluorescence in‐situ hybridization (FISH) analysis using a probe which maps to the chromosome band 22q11 and 22q13, allowing us to show deletion or loss of one chromosome 22 in the tumour cells. Conclusions: This case may be considered a new variant of perineurioma with Pacinian‐like features, for which we propose the designation ‘sclerosing Pacinian‐like perineurioma’.