Serum osteoprotegerin levels are associated with inflammation and pulse wave velocity

• Published in: Clinical endocrinology (Oxford) Vol. 63; no. 5; pp. 594 - 598
• Main Authors: Kim, S. M., Lee, J., Ryu, O. H., Lee, K. W., Kim, H. Y., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, D. S., Choi, K. M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.11.2005; Blackwell; Wiley Subscription Services, Inc
• Subjects: Biological and medical sciences; Biomarkers - blood; Blood Glucose - analysis; Brachial Artery - physiopathology; C-Reactive Protein - analysis; Case-Control Studies; Diabetes Mellitus - blood; Diabetes Mellitus - physiopathology; Endocrinopathies; Female; Fundamental and applied biological sciences. Psychology; Glycoproteins - blood; Humans; Hypertension - blood; Hypertension - physiopathology; Inflammation - blood; Inflammation - physiopathology; Insulin Resistance; Interleukin-6 - blood; Lipids - blood; Male; Medical sciences; Middle Aged; Osteoprotegerin; Pulsatile Flow; Receptors, Cytoplasmic and Nuclear - blood; Receptors, Tumor Necrosis Factor - blood; Regression Analysis; Signal Processing, Computer-Assisted; Systole; Triglycerides - blood; Vertebrates: endocrinology; Serum; Inflammation; Arterial pulse; Velocity; Endocrinology; Osteoprotegerin
• ISSN: 0300-0664; 1365-2265
• DOI: 10.1111/j.1365-2265.2005.02390.x

Summary Objective  We examined the association between serum osteoprotegerin (OPG) levels, systemic inflammation and arterial stiffness in normal and diabetic patients. Patients and measurements  The study subjects comprised 49 newly diagnosed diabetic patients and 72 age‐ and sex‐matched normal glucose controls. Anthropometric parameters, blood pressure, fasting blood glucose (FBG), lipid profiles, serum OPG, high‐sensitive C‐reactive protein (hsCRP), interleukin‐6 (IL‐6) and brachial‐ankle pulse wave velocity (baPWV) were measured. Results  Serum OPG levels (6·1 ± 1·4 vs. 5·4 ± 1·3 pmol/l, P = 0·011) and baPWV (1562 ± 354 vs. 1399 ± 257 cm/s, P = 0·004) were significantly higher in the diabetic group than in the normal glucose group. Serum OPG levels in normal and diabetic patients correlated significantly with systolic blood pressure (r = 0·20, P = 0·035), FBG (r = 0·30, P = 0·002), right baPWV (r = 0·22, P = 0·021), left baPWV (r = 0·26, P = 0·006), homeostasis model assessment insulin resistance (HOMA‐IR) (r = 0·19, P = 0·045), IL‐6 (r = 0·32, P = 0·001) and hsCRP (r = 0·21, P = 0·027) after adjusting for age and sex. Multiple regression analysis showed that serum OPG level was significantly associated with age, FBG, IL‐6, systolic blood pressure, triglyceride and hsCRP (R2 = 0·299). Conclusions  In summary, serum OPG and baPWV levels are elevated in diabetic patients and serum OPG levels are significantly associated with inflammation and arterial stiffness.