What Is the Real Contribution of Extrahepatic Cells to Liver Regeneration?

Extrahepatic cells, especially bone marrow (BM) cells, might contribute to liver repair, but recent published evidence suggests that they do not play a role in the normally regenerating liver. The mechanism by which extrahepatic cells express a liver-specific function in the liver, whether by transd...

Full description

Saved in:
Bibliographic Details
Published inSurgery today (Tokyo, Japan) Vol. 39; no. 1; pp. 1 - 4
Main Authors Eguchi, Susumu, Kanematsu, Takashi
Format Journal Article
LanguageEnglish
Published Japan Springer Japan 01.01.2009
Subjects
Animals
Bone Marrow Cells - physiology
Bone Marrow Transplantation
Cell Fusion
Cell Transdifferentiation - physiology
Extrahepatic stem cells
Green Fluorescent Proteins
Hepatectomy
Humans
Liver Diseases - surgery
Liver regeneration
Liver Regeneration - physiology
Medicine
Medicine & Public Health
Review Article
Surgery
Surgical Oncology
Transdifferentiation
Cell fusion
Extrahepatic stem cells
Transdifferentiation
Liver regeneration
Online AccessGet full text

Cover

More Information
Summary:Extrahepatic cells, especially bone marrow (BM) cells, might contribute to liver repair, but recent published evidence suggests that they do not play a role in the normally regenerating liver. The mechanism by which extrahepatic cells express a liver-specific function in the liver, whether by transdifferentiation or by cell fusion, remains unclear. In this review, we investigate the status of findings on this controversial subject and summarize the recent research.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-008-3836-1