Meprobamate kinetics during and after terminated hemoperfusion in acute intoxications

• Published in: Journal of toxicology. Clinical toxicology Vol. 25; no. 4; p. 317
• Main Authors: Jacobsen, D, Wiik-Larsen, E, Saltvedt, E, Bredesen, J E
• Format: Journal Article
• Language: English
• Published: United States 1987
• Subjects: Adult; Female; Half-Life; Hemoperfusion; Humans; Meprobamate - blood; Meprobamate - pharmacokinetics; Meprobamate - poisoning; Metabolic Clearance Rate; Middle Aged; Resuscitation; Suicide, Attempted
• ISSN: 0731-3810
• DOI: 10.3109/15563658708992635

We report four cases of severe meprobamate intoxication. Maximal plasma levels reached 800 (176), 816 (180), 863 (190) and 923 mumol/l (203 mg/l). All patients survived without sequelae including one patient resuscitated from cardiac arrest. The clinical course was complicated by coma, hypotension, and hypothermia in all patients. Three cases were treated with charcoal hemoperfusion with mean hemoperfusion clearance ranging from 134-164 ml/min compared to 174 ml/min in one case treated with resin filter and the same blood flow of 200 ml/min. In two cases, a mean renal meprobamate clearance of 15 and 23 ml/min was calculated comprising only 9-15% of the hemoperfusion clearance. The amount of meprobamate removed by hemoperfusion ranged from 1.6-6.2 g. In one case, the half-life of plasma meprobamate during hemoperfusion was 2.6 hours compared to 8.3 hours after hemoperfusion. Thus the half-life was reduced more than 3-fold. These data show that hemoperfusion may be indicated in severe meprobamate intoxication.