Anesthetic Efficacy of Four Percent Articaine for Pulpal Anesthesia by Using Inferior Alveolar Nerve Block and Buccal Infiltration Techniques in Patients with Irreversible Pulpitis: A Prospective Randomized Double-blind Clinical Trial

• Published in: Journal of endodontics Vol. 37; no. 12; pp. 1603 - 1607
• Main Authors: Poorni, Saravanan, Veniashok, Baskaran, Senthilkumar, Ayyampudur Durairaj, Indira, Rajamani, Ramachandran, Sundararaman
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2011
• Subjects: Adolescent; Adult; Anesthesia, Dental; Anesthetics, Local - administration & dosage; Articaine; buccal infiltration; Carticaine - administration & dosage; Cheek - innervation; Dental Pulp - innervation; Dentistry; Double-Blind Method; Endocrinology & Metabolism; Epinephrine - administration & dosage; Female; Humans; Injections; irreversible pulpitis; Lidocaine - administration & dosage; Male; Mandibular Nerve - drug effects; Molar - pathology; Nerve Block - methods; Pain Measurement; Prospective Studies; pulpal anesthesia; Pulpectomy - instrumentation; Pulpitis - therapy; Root Canal Preparation - methods; Treatment Outcome; Vasoconstrictor Agents - administration & dosage; Young Adult; irreversible pulpitis; Articaine; pulpal anesthesia; buccal infiltration
• ISSN: 0099-2399; 1878-3554; 1878-3554
• DOI: 10.1016/j.joen.2011.09.009

The study was designed as a randomized double-blind trial to evaluate the anesthetic efficacy of 4% articaine with 1:100,000 epinephrine in inferior alveolar nerve block (IANB) and infiltration anesthetic techniques to anesthetize mandibular molars with irreversible pulpitis. The study was composed of 2 test arms and 1 control arm. Subjects in the test arms received either a standard IANB or a buccal infiltration (B Infil) of 4% articaine with 1:100,000 epinephrine, whereas the subjects in the control arm received a standard IANB of 2% lidocaine with 1:100,000 epinephrine. Subject’s self-reported pain response was recorded on Heft Parker Visual Analogue Scale after local anesthetic administration during access preparation and pulp extirpation. For statistical analysis Pearson χ 2, Student's paired t test, 1-way analysis of variance, and Friedman tests showed no significant difference in success rates among the 3 arms of the trial. Although B Infil and IANB of 4% articaine were equally effective, B Infil can be considered a viable alterative in IANB for pulpal anesthesia in mandibular molars with irreversible pulpitis.