Therapeutic Effect of Curcumin on 5/6Nx Hypertriglyceridemia: Association with the Improvement of Renal Mitochondrial β-Oxidation and Lipid Metabolism in Kidney and Liver

Chronic kidney disease (CKD) prevalence is constantly increasing, and dyslipidemia in this disease is characteristic, favoring cardiovascular events. However, the mechanisms of CKD dyslipidemia are not fully understood. The use of curcumin (CUR) in CKD models such as 5/6 nephrectomy (5/6Nx) has show...

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Published inAntioxidants Vol. 11; no. 11; p. 2195
Main Authors Ceja-Galicia, Zeltzin Alejandra, García-Arroyo, Fernando Enrique, Aparicio-Trejo, Omar Emiliano, El-Hafidi, Mohammed, Gonzaga-Sánchez, Guillermo, León-Contreras, Juan Carlos, Hernández-Pando, Rogelio, Guevara-Cruz, Martha, Tovar, Armando R., Rojas-Morales, Pedro, Aranda-Rivera, Ana Karina, Sánchez-Lozada, Laura Gabriela, Tapia, Edilia, Pedraza-Chaverri, José
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 06.11.2022
MDPI
Subjects
Adenosine triphosphate
Animals
Antibodies
Cholesterol
chronic kidney disease (CKD)
Creatinine
Curcumin
Depolarization
Dyslipidemia
Fatty acids
High density lipoprotein
Hypertriglyceridemia
Kidney diseases
Kidneys
Lipid metabolism
Lipids
Lipogenesis
Lipoproteins
Liver
liver alteration in CKD
Liver diseases
Membrane potential
Metabolic disorders
Mitochondria
mitochondrial dysfunction
Nephrectomy
Oxidation
Plasma
Proteins
Surgery
Triglycerides
United States > US
Indianapolis Indiana
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Abstract Chronic kidney disease (CKD) prevalence is constantly increasing, and dyslipidemia in this disease is characteristic, favoring cardiovascular events. However, the mechanisms of CKD dyslipidemia are not fully understood. The use of curcumin (CUR) in CKD models such as 5/6 nephrectomy (5/6Nx) has shown multiple beneficial effects, so it has been proposed to correct dyslipidemia without side effects. This work aimed to characterize CUR’s potential therapeutic effect on dyslipidemia and alterations in lipid metabolism and mitochondrial ß-oxidation in the liver and kidney in 5/6Nx. Male Wistar rats were subjected to 5/6Nx and progressed by 4 weeks; meanwhile, CUR (120 mg/kg) was administered for weeks 5 to 8. Our results showed that CUR reversed the increase in liver and kidney damage and hypertriglyceridemia induced by 5/6Nx. CUR also reversed mitochondrial membrane depolarization and β-oxidation disorders in the kidney and the increased lipid uptake and the high levels of proteins involved in fatty acid synthesis in the liver and kidney. CUR also decreased lipogenesis and increased mitochondrial biogenesis markers in the liver. Therefore, we concluded that the therapeutic effect of curcumin on 5/6Nx hypertriglyceridemia is associated with the restoration of renal mitochondrial ß-oxidation and the reduction in lipid synthesis and uptake in the kidneys and liver.
AbstractList Chronic kidney disease (CKD) prevalence is constantly increasing, and dyslipidemia in this disease is characteristic, favoring cardiovascular events. However, the mechanisms of CKD dyslipidemia are not fully understood. The use of curcumin (CUR) in CKD models such as 5/6 nephrectomy (5/6Nx) has shown multiple beneficial effects, so it has been proposed to correct dyslipidemia without side effects. This work aimed to characterize CUR’s potential therapeutic effect on dyslipidemia and alterations in lipid metabolism and mitochondrial ß-oxidation in the liver and kidney in 5/6Nx. Male Wistar rats were subjected to 5/6Nx and progressed by 4 weeks; meanwhile, CUR (120 mg/kg) was administered for weeks 5 to 8. Our results showed that CUR reversed the increase in liver and kidney damage and hypertriglyceridemia induced by 5/6Nx. CUR also reversed mitochondrial membrane depolarization and β-oxidation disorders in the kidney and the increased lipid uptake and the high levels of proteins involved in fatty acid synthesis in the liver and kidney. CUR also decreased lipogenesis and increased mitochondrial biogenesis markers in the liver. Therefore, we concluded that the therapeutic effect of curcumin on 5/6Nx hypertriglyceridemia is associated with the restoration of renal mitochondrial ß-oxidation and the reduction in lipid synthesis and uptake in the kidneys and liver.
Author Hernández-Pando, Rogelio
Aranda-Rivera, Ana Karina
León-Contreras, Juan Carlos
Guevara-Cruz, Martha
Aparicio-Trejo, Omar Emiliano
Tovar, Armando R
Gonzaga-Sánchez, Guillermo
Ceja-Galicia, Zeltzin Alejandra
Pedraza-Chaverri, José
García-Arroyo, Fernando Enrique
Tapia, Edilia
El-Hafidi, Mohammed
Rojas-Morales, Pedro
Sánchez-Lozada, Laura Gabriela
AuthorAffiliation 5 Department of Nutrition Physiology, National Institute of Medical Science and Nutrition “Salvador Zubirán”, Mexico City 14080, Mexico
4 Department of Experimental Pathology, National Institute of Medical Science and Nutrition “Salvador Zubirán”, Mexico City 14080, Mexico
2 Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Mexico City 04510, Mexico
3 Department of Cardiovascular Biomedicine, National Institute of Cardiology “Ignacio Chávez”, Mexico City 14080, Mexico
1 Department of Cardio-Renal Physiology, National Institute of Cardiology “Ignacio Chávez”, Mexico City 14080, Mexico
AuthorAffiliation_xml – name: 4 Department of Experimental Pathology, National Institute of Medical Science and Nutrition “Salvador Zubirán”, Mexico City 14080, Mexico
– name: 3 Department of Cardiovascular Biomedicine, National Institute of Cardiology “Ignacio Chávez”, Mexico City 14080, Mexico
– name: 1 Department of Cardio-Renal Physiology, National Institute of Cardiology “Ignacio Chávez”, Mexico City 14080, Mexico
– name: 2 Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Mexico City 04510, Mexico
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Snippet Chronic kidney disease (CKD) prevalence is constantly increasing, and dyslipidemia in this disease is characteristic, favoring cardiovascular events. However,...
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SubjectTerms Adenosine triphosphate
Animals
Antibodies
Cholesterol
chronic kidney disease (CKD)
Creatinine
Curcumin
Depolarization
Dyslipidemia
Fatty acids
High density lipoprotein
Hypertriglyceridemia
Kidney diseases
Kidneys
Lipid metabolism
Lipids
Lipogenesis
Lipoproteins
Liver
liver alteration in CKD
Liver diseases
Membrane potential
Metabolic disorders
Mitochondria
mitochondrial dysfunction
Nephrectomy
Oxidation
Plasma
Proteins
Surgery
Triglycerides
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Title Therapeutic Effect of Curcumin on 5/6Nx Hypertriglyceridemia: Association with the Improvement of Renal Mitochondrial β-Oxidation and Lipid Metabolism in Kidney and Liver
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Volume 11
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