Therapeutic Effect of Curcumin on 5/6Nx Hypertriglyceridemia: Association with the Improvement of Renal Mitochondrial β-Oxidation and Lipid Metabolism in Kidney and Liver

• Published in: Antioxidants Vol. 11; no. 11; p. 2195
• Main Authors: Ceja-Galicia, Zeltzin Alejandra, García-Arroyo, Fernando Enrique, Aparicio-Trejo, Omar Emiliano, El-Hafidi, Mohammed, Gonzaga-Sánchez, Guillermo, León-Contreras, Juan Carlos, Hernández-Pando, Rogelio, Guevara-Cruz, Martha, Tovar, Armando R., Rojas-Morales, Pedro, Aranda-Rivera, Ana Karina, Sánchez-Lozada, Laura Gabriela, Tapia, Edilia, Pedraza-Chaverri, José
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 06.11.2022; MDPI
• Subjects: Adenosine triphosphate; Animals; Antibodies; Cholesterol; chronic kidney disease (CKD); Creatinine; Curcumin; Depolarization; Dyslipidemia; Fatty acids; High density lipoprotein; Hypertriglyceridemia; Kidney diseases; Kidneys; Lipid metabolism; Lipids; Lipogenesis; Lipoproteins; Liver; liver alteration in CKD; Liver diseases; Membrane potential; Metabolic disorders; Mitochondria; mitochondrial dysfunction; Nephrectomy; Oxidation; Plasma; Proteins; Surgery; Triglycerides; United States > US; Indianapolis Indiana
• ISSN: 2076-3921; 2076-3921
• DOI: 10.3390/antiox11112195

Chronic kidney disease (CKD) prevalence is constantly increasing, and dyslipidemia in this disease is characteristic, favoring cardiovascular events. However, the mechanisms of CKD dyslipidemia are not fully understood. The use of curcumin (CUR) in CKD models such as 5/6 nephrectomy (5/6Nx) has shown multiple beneficial effects, so it has been proposed to correct dyslipidemia without side effects. This work aimed to characterize CUR’s potential therapeutic effect on dyslipidemia and alterations in lipid metabolism and mitochondrial ß-oxidation in the liver and kidney in 5/6Nx. Male Wistar rats were subjected to 5/6Nx and progressed by 4 weeks; meanwhile, CUR (120 mg/kg) was administered for weeks 5 to 8. Our results showed that CUR reversed the increase in liver and kidney damage and hypertriglyceridemia induced by 5/6Nx. CUR also reversed mitochondrial membrane depolarization and β-oxidation disorders in the kidney and the increased lipid uptake and the high levels of proteins involved in fatty acid synthesis in the liver and kidney. CUR also decreased lipogenesis and increased mitochondrial biogenesis markers in the liver. Therefore, we concluded that the therapeutic effect of curcumin on 5/6Nx hypertriglyceridemia is associated with the restoration of renal mitochondrial ß-oxidation and the reduction in lipid synthesis and uptake in the kidneys and liver.