Ball pen writing-without-ink: a truly simple and accessible method for sensitivity enhancement in lateral flow assays

Lateral flow assays (LFAs), a popular point-of-care testing platform, have found widespread applications from laboratory to clinics. However, LFA-based testing is still subject to limited detection sensitivity, especially for classical gold nanoparticle-based LFAs. Inspired by traditional pen-based...

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Bibliographic Details
Published inRSC advances Vol. 12; no. 4; pp. 268 - 273
Main Authors Li, Zedong, Wu, Shuang, Ji, Jingcheng, Bai, Yuemeng, Jia, Pengpeng, Gong, Yan, Feng, Shangsheng, Li, Fei
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 13.01.2022
The Royal Society of Chemistry
Subjects
Chemistry
detection limit
Flow velocity
Fluid dynamics
Fluid flow
gold
liquids
Nanoparticles
Sensitivity enhancement
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Summary:Lateral flow assays (LFAs), a popular point-of-care testing platform, have found widespread applications from laboratory to clinics. However, LFA-based testing is still subject to limited detection sensitivity, especially for classical gold nanoparticle-based LFAs. Inspired by traditional pen-based writing technologies, we developed a ball pen writing-without-ink method to amplify the detection signal of LFAs through controlling fluid flow rate. An enhancement of detection sensitivity by two times was obtained. Since the underlying mechanism of this method to improve detection sensitivity is to control the flow rate of the liquid on paper, it may be suitable for most paper-based platforms. A ball pen writing-without-ink method was developed to amplify the detection signal of LFAs through controlling fluid flow rate.
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The authors contributed equally.
ISSN:2046-2069
2046-2069
DOI:10.1039/d1ra07684a