Risk Factors and Comorbidities Associated With the Allergic Rhinitis Phenotype in Children According to the ARIA Classification

• Published in: Allergy, asthma & immunology research Vol. 12; no. 1; pp. 72 - 85
• Main Authors: Jung, Sungsu, Lee, So Yeon, Yoon, Jisun, Cho, Hyun Ju, Kim, Young Ho, Suh, Dong In, Yang, Song I, Kwon, Ji Won, Jang, Gwang Cheon, Sun, Yong Han, Woo, Sung Il, Youn, You Sook, Park, Kang Seo, Lee, Eun, Cho, Hwa Jin, Kook, Myung Hee, Yi, Hye Ryoung, Chung, Hai Lee, Kim, Ja Hyeong, Kim, Hyung Young, Jung, Jin A, Woo, Hyang Ok, Lee, Jeom Kyu, Chang, Woo Sung, Do, Nam Hee, Cho, Hyejoo, Hong, Soo Jong
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Academy of Asthma, Allergy and Clinical Immunology 01.01.2020; The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease; 대한천식알레르기학회
• Subjects: Allergens; Allergic rhinitis; Allergies; Analgesics; Asthma; Children; Classification; Confidence intervals; Correlation analysis; Disease control; Genotype & phenotype; Original; Phenotypes; Population studies; Rhinitis; Risk analysis; Risk factors; Skin tests; 내과학; phenotype; prevalence; cohort study; Allergic rhinitis; classification; bronchial hyperreactivity; risk factor; child
• ISSN: 2092-7355; 2092-7363
• DOI: 10.4168/aair.2020.12.1.72

Data are lacking on the association between the allergic rhinitis (AR) phenotype and sensitization to specific allergens or bronchial hyperresponsiveness (BHR) in children. We here investigated risk factors and comorbidities, including sensitization to specific allergens and BHR, for the AR phenotype by AR and its Impact on Asthma (ARIA) classification in a general population-based birth cohort study. We enrolled 606 children aged 7 years from the Panel Study of Korean Children. The AR phenotype was assigned in accordance with the ARIA classification in children. Skin prick tests and Provocholine provocation test were performed. Risk factors and comorbidities for AR phenotypes were then analyzed. The prevalence of mild and moderate to severe AR in our study cohort was 37.2% and 8.8%, respectively. Recent use of analgesics or antipyretics and current cat ownership were associated with the risk of mild persistent AR. Sensitizations to ( ), Japanese hop and cat were associated with moderate to severe persistent AR. Children with moderate to severe AR had a higher risk of current asthma and BHR compared to mild AR cases (adjusted odds ratio [aOR], 5.26; 95% confidence interval [CI], 1.77-15.62). Moderate to severe AR with allergic sensitization was associated with the highest risk of BHR (aOR, 11.77; 95% CI, 3.40-40.74). Moderate to severe-persistent AR is more closely related to respiratory comorbidities and sensitizations than mild AR. Stratifying the AR phenotype by ARIA classification may assist in disease management.