Ethanol-induced CD3 and CD2 hyporesponsiveness of peripheral blood T lymphocytes
The functional relevance of a direct ethanol effect on the membrane structure of T lymphocytes and accessory cells (APC), as well as on signal transduction systems was studied in ten normal subjects. Ethanol incubation (80 mM for 24h) of highly purified T cells increased the number of CD4+/CD45RA+ l...
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Published in | Immunopharmacology and immunotoxicology Vol. 14; no. 4; p. 939 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
1992
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Subjects | |
Online Access | Get more information |
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Summary: | The functional relevance of a direct ethanol effect on the membrane structure of T lymphocytes and accessory cells (APC), as well as on signal transduction systems was studied in ten normal subjects. Ethanol incubation (80 mM for 24h) of highly purified T cells increased the number of CD4+/CD45RA+ lymphocytes. In contrast, ethanol exposure induced a drop in CD14+/LFA-3+ APC values. These changes were accompanied by faulty T-cell proliferation in response to anti-CD3 and anti-CD2 mAb and inhibition of CD3- and CD2-mediated rises in intracellular calcium and, to a lesser extent, inositol 1,4,5-triphosphate levels. These data clearly indicate that a membrane-specific ethanol interaction both modifies surface glycoproteic and/or glycolipidic structures and alters transmembrane transduction of the activation signals. |
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ISSN: | 0892-3973 |
DOI: | 10.3109/08923979209009243 |