Ethanol-induced CD3 and CD2 hyporesponsiveness of peripheral blood T lymphocytes

The functional relevance of a direct ethanol effect on the membrane structure of T lymphocytes and accessory cells (APC), as well as on signal transduction systems was studied in ten normal subjects. Ethanol incubation (80 mM for 24h) of highly purified T cells increased the number of CD4+/CD45RA+ l...

Full description

Saved in:
Bibliographic Details
Published inImmunopharmacology and immunotoxicology Vol. 14; no. 4; p. 939
Main Authors Spinozzi, F, Agea, E, Fiorucci, G, Gerli, R, Muscat, C, Belia, S, Bertotto, A
Format Journal Article
LanguageEnglish
Published England 1992
Subjects
Online AccessGet more information

Cover

Loading…
More Information
Summary:The functional relevance of a direct ethanol effect on the membrane structure of T lymphocytes and accessory cells (APC), as well as on signal transduction systems was studied in ten normal subjects. Ethanol incubation (80 mM for 24h) of highly purified T cells increased the number of CD4+/CD45RA+ lymphocytes. In contrast, ethanol exposure induced a drop in CD14+/LFA-3+ APC values. These changes were accompanied by faulty T-cell proliferation in response to anti-CD3 and anti-CD2 mAb and inhibition of CD3- and CD2-mediated rises in intracellular calcium and, to a lesser extent, inositol 1,4,5-triphosphate levels. These data clearly indicate that a membrane-specific ethanol interaction both modifies surface glycoproteic and/or glycolipidic structures and alters transmembrane transduction of the activation signals.
ISSN:0892-3973
DOI:10.3109/08923979209009243