Genetic drift in mammals

Genetic drift is the fortuitous occurrence of genetic events that when they become fixed modify the genome of populations. They can take the form of mutations of single nucleotides (SNPs), the insertion or deletion of short sequences (Indels) or the repetitions of short sequences (CNV i.e. copy numb...

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Published inAnais da Academia Brasileira de Ciências Vol. 91; no. suppl 3; p. e20190339
Main Author Bach, Jean-François
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Academia Brasileira de Ciências 01.01.2019
Subjects
de novo mutations
genetic drift
genome of populations
inbred mouse strains
MULTIDISCIPLINARY SCIENCES
genome of populations
inbred mouse strains
genetic drift
de novo mutations
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Summary:Genetic drift is the fortuitous occurrence of genetic events that when they become fixed modify the genome of populations. They can take the form of mutations of single nucleotides (SNPs), the insertion or deletion of short sequences (Indels) or the repetitions of short sequences (CNV i.e. copy number variants) or long insertions or deletion (structural modifications). Their frequency is 10-9 to 10-8 depending on the species, or 50 to 100 per birth in humans. The incidence of these de novo mutations is higher when the father is old at conception. It thus appears that genetic drift, which constitutes the initial element of evolution, has a very strong dynamics. Its intervention in the appearance or disappearance of some major phenotypes is complicated by the uncertainties about the genetic mechanisms in heritability which, paradoxically, are only partially understood.
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ISSN:0001-3765
1678-2690
1678-2690
DOI:10.1590/0001-3765201920190339