Low-dose chronic inhalation of diesel exhaust and/or coal dust by rats: effect of age and exposure on lung and liver cytochrome P-450

Rats were exposed by inhalation to low levels of diesel exhaust and/or coal dust, seven hours/day, five days/week for 24 months. Cytochrome P-450-associated benzo[a]pyrene hydroxylase and 7-ethoxycoumarin deethylase activities were assayed in lung and liver microsomes after 3, 6, and 24 months. When...

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Bibliographic Details
Published inXenobiotica Vol. 14; no. 7; p. 595
Main Authors Rabovsky, J, Marion, K J, Groseclose, R D, Lewis, T R, Petersen, M
Format Journal Article
LanguageEnglish
Published England 01.01.1984
Subjects
7-Alkoxycoumarin O-Dealkylase
Aging
Air Pollution - adverse effects
Animals
Benzopyrene Hydroxylase - metabolism
Coal - adverse effects
Cytochrome P-450 Enzyme System - metabolism
Dust - adverse effects
Lung - enzymology
Male
Microsomes - enzymology
Microsomes, Liver - enzymology
Oxygenases - metabolism
Petroleum - adverse effects
Rats
Rats, Inbred F344
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Summary:Rats were exposed by inhalation to low levels of diesel exhaust and/or coal dust, seven hours/day, five days/week for 24 months. Cytochrome P-450-associated benzo[a]pyrene hydroxylase and 7-ethoxycoumarin deethylase activities were assayed in lung and liver microsomes after 3, 6, and 24 months. When data were analysed across all time intervals and adjusted for age, lower benzo[a]pyrene hydroxylase activity was observed in lung microsomes from rats exposed to diesel exhaust plus coal dust than in those exposed to coal dust alone. Data are discussed in terms of interaction between diesel exhaust and coal dust and effect of infectious agents.
ISSN:0049-8254
DOI:10.3109/00498258409151454