Fatal intoxication with amlodipine

Although poisoning with calcium channel blocking agents is frequent, to our knowledge no cases involving amlodipine have been published. We describe here a case of amlodipine intoxication, in which protracted hypotension did not respond to vasopressor therapy alone. After the addition of continuous...

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Bibliographic Details
Published inJournal of toxicology. Clinical toxicology Vol. 33; no. 3; p. 253
Main Authors Koch, A R, Vogelaers, D P, Decruyenaere, J M, Callens, B, Verstraete, A, Buylaert, W A
Format Journal Article
LanguageEnglish
Published United States 1995
Subjects
Amlodipine - poisoning
Fatal Outcome
Female
Humans
Hypotension - chemically induced
Middle Aged
Oxazepam - poisoning
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Summary:Although poisoning with calcium channel blocking agents is frequent, to our knowledge no cases involving amlodipine have been published. We describe here a case of amlodipine intoxication, in which protracted hypotension did not respond to vasopressor therapy alone. After the addition of continuous calcium chloride and glucagon infusion, blood pressure was restored and vasopressor therapy could be tapered off substantially. When calcium and glucagon were interrupted because of severe hypercalcemia and hyperglycemia, the patient developed irreversible hypotension and died. Either glucagon or calcium or both, and to some extent vasopressors, seem to have constituted effective treatment of hypotension in this case.
ISSN:0731-3810
DOI:10.3109/15563659509017993