Nonaccidental endosulfan intoxication: a case report with toxicokinetic calculations and tissue concentrations

A case of nonaccidental endosulfan intoxication in a previously healthy 43-year-old male patient is reported. On admission, the patient had few symptoms, but refractory seizures began 1 hour after ingestion. The patient died on the fourth day after admission showing clinical signs of cerebral hernia...

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Bibliographic Details
Published inJournal of toxicology. Clinical toxicology Vol. 36; no. 4; p. 345
Main Authors Boereboom, F T, van Dijk, A, van Zoonen, P, Meulenbelt, J
Format Journal Article
LanguageEnglish
Published United States 1998
Subjects
Adult
Area Under Curve
Brain - drug effects
Chromatography, Gas
Encephalocele - chemically induced
Endosulfan - pharmacokinetics
Endosulfan - poisoning
Fatal Outcome
Humans
Hydrocarbons, Chlorinated
Insecticides - pharmacokinetics
Insecticides - poisoning
Male
Suicide
Tissue Distribution
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Summary:A case of nonaccidental endosulfan intoxication in a previously healthy 43-year-old male patient is reported. On admission, the patient had few symptoms, but refractory seizures began 1 hour after ingestion. The patient died on the fourth day after admission showing clinical signs of cerebral herniation confirmed at autopsy. Blood, urine, and tissue samples were analyzed for alpha-endosulfan, beta-endosulfan, and endosulfan sulfate by capillary gas chromatography with electron capture detection. Concentration versus time data for endosulfan were fitted using the program MW/Pharm, assuming complete bioavailability although it is recognized that the bioavailability of endosulfan after ingestion may have been low and the calculated clearance was primarily due to redistribution. Hemoperfusion was shown to be ineffective.
ISSN:0731-3810
DOI:10.3109/15563659809028031