Inhibitory effect of anaphylactic reaction of Sosiho-Tang

• Published in: Immunopharmacology and immunotoxicology Vol. 20; no. 4; p. 567
• Main Authors: Kim, H M, Kim, Y Y, Moon, H S, Lee, E H, Moon, S J, An, N H
• Format: Journal Article
• Language: English
• Published: England 01.01.1998
• Subjects: Animals; Dinitrobenzenes - immunology; Drugs, Chinese Herbal - therapeutic use; Histamine Release - drug effects; Immunoglobulin E - immunology; Male; Mast Cells - drug effects; Mast Cells - immunology; Mast Cells - secretion; Mice; Mice, Inbred BALB C; p-Methoxy-N-methylphenethylamine - immunology; p-Methoxy-N-methylphenethylamine - toxicity; Passive Cutaneous Anaphylaxis - drug effects; Passive Cutaneous Anaphylaxis - immunology; Rats; Rats, Wistar
• ISSN: 0892-3973
• DOI: 10.3109/08923979809031517

Mast cells synthesize and secrete chemical mediators which play an central role in anaphylactic reactions. Compound 48/80 is a condensation product of formaldehyde with paramethoxyphenylethylamine that reliably induces the release of chemical mediators in the mast cell granules. Aggregation of the high-affinity Fc receptor also stimulates the mast cells. The objective of the current study was to determine the effect of Sosiho-Tang (SS-Tang) on mast cell-mediated anaphylactic reaction. SS-Tang completely inhibited systemic anaphylaxis induced by compound 48/80 in mice. SS-Tang inhibited local anaphylaxis induced by anti-dinitrophenyl (DNP) IgE. In addition SS-Tang concentration-dependently inhibited histamine release in mast cells induced by compound 48/80 or anti-DNP IgE. These results indicate that SS-Tang may contain compounds with actions that inhibit mast cell degranulation.