Recent behavioral findings of pathophysiological involvement of lactate in the central nervous system

• Published in: Biochimica et biophysica acta. General subjects Vol. 1866; no. 7; p. 130137
• Main Author: Kambe, Yuki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2022
• Subjects: Animal behavior; Astrocytes; Astrocytes - metabolism; Brain - metabolism; central nervous system; Central Nervous System - metabolism; energy; glucose; glycogen; Glycogen - metabolism; glycolysis; Lactate; lactic acid; Lactic Acid - metabolism; Neurons; pathophysiology; astrocyte-neuron lactate shuttle; medial prefrontal cortex; Lactate; amyloid β; conditioned place preference; forced swimming test; pyruvate kinase M; adeno-associated virus; AMP-activated protein kinase; designer receptors exclusively activated by designer drugs; vasoactive intestinal peptide; G-protein coupled receptor; amyloid precursor protein; reactive oxygen species; TAR DNA-binding protein 43; basolateral amygdala; Noradrenaline; presenilin1; inhibitory avoidance test; knockout; Astrocytes; Neurons; pituitary adenylate cyclase-activating polypeptide; lactate dehydrogenase; monocarboxylic acid transporters; novel object recognition; oxidative phosphorylation; α-cyano-4-hydroxycinnamate; cannabinoid receptor type 1; disrupted in schizophrenia 1; streptozotocin; Animal behavior; Alzheimer's Disease; amyotrophic Lateral Sclerosis; superoxide dismutase; 1,4-dideoxy-1,4-imino-D-arabinitol; apolipoprotein E; lipopolysaccharide; glial fibrillary acidic protein; elevated plus-maze test; n-methyl-D-aspartate
• ISSN: 0304-4165; 1872-8006; 1872-8006
• DOI: 10.1016/j.bbagen.2022.130137

Lactate was initially thought of as a fatigue substance. In recent years, however, lactate not only functions as an energy carrier and contributes to ATP production, but also its role as a signal transmitter has been attracting attention due to the identification of lactate receptors. Lactate is synthesized from glucose and glycogen through the glycolytic system. The central nervous system is a major organ of glucose metabolism and is rich in glycogen. Therefore, this review summarizes the recent findings on the contribution of lactate to the pathophysiology of the central nervous system. •Effects of lactate signaling on animal behavior.•Extracellular signals that activate lactate metabolism in astrocytes.•Effects of lactate signaling on neurons.