Differential Dependence of Hypoxia-inducible Factors 1α and 2α on mTORC1 and mTORC2

• Published in: The Journal of biological chemistry Vol. 283; no. 50; pp. 34495 - 34499
• Main Authors: Toschi, Alfredo, Lee, Evan, Gadir, Noga, Ohh, Michael, Foster, David A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.12.2008; American Society for Biochemistry and Molecular Biology
• Subjects: Accelerated Publications; Adaptor Proteins, Signal Transducing; Basic Helix-Loop-Helix Transcription Factors - metabolism; Carrier Proteins - metabolism; Cell Line, Tumor; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Mechanistic Target of Rapamycin Complex 1; Models, Biological; Multiprotein Complexes; Proteins - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Rapamycin-Insensitive Companion of mTOR Protein; Regulatory-Associated Protein of mTOR; RNA, Small Interfering - metabolism; Sirolimus - pharmacology; TOR Serine-Threonine Kinases; Transcription Factors - metabolism

Constitutive expression of hypoxia-inducible factor (HIF) has been implicated in several proliferative disorders. Constitutive expression of HIF1α and HIF2α has been linked to a number of human cancers, especially renal cell carcinoma (RCC), in which HIF2α expression is the more important contributo...