Increased arterial stiffness elevates the risk of heart failure in diabetic patients

• Published in: International journal of cardiology Vol. 385; pp. 26 - 33
• Main Authors: Wu, Lili, Wu, Meimei, Zhang, Xuelian, Chen, Shuohua, Wang, Guodong, Wu, Shouling, Zhuang, Jinqiang, Hong, Jiang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.08.2023
• Subjects: Ankle Brachial Index; Arterial stiffness; Diabetes Mellitus; Heart Failure; Humans; Prospective study; Pulse Wave Analysis; Risk Factors; Vascular Stiffness - physiology; Heart failure; SBP; eGFR; baPWV; Arterial stiffness; AF; LDL-C; Diabetes mellitus; CI; FBG; HR; TC; HDL-C; SD; AS; DBP; TG; hsCRP; MI; Prospective study; CKD; HF; BMI
• ISSN: 0167-5273; 1874-1754; 1874-1754
• DOI: 10.1016/j.ijcard.2023.05.039

Previous studies have shown that arterial stiffness (AS) was a risk factor for heart failure (HF) in nondiabetic patients. We aimed to analyze this impact in a community-based diabetic population. Our study excluded those who had HF before brachial-ankle pulse wave velocity (baPWV) measurement and included 9041 participants finally. Subjects were divided into the normal (<14 m/s), intermediate (14–18 m/s), and elevated baPWV groups (>18 m/s) based on baPWV values. Multivariate Cox proportional hazard model was used to analyze the effect of AS on HF risk. During the median follow-up of 4.19 years, 213 patients had HF. The results of Cox model showed that HF risk in the elevated baPWV group was 2.25 times higher than that in the normal baPWV group (95% confidence interval [CI]: 1.24–4.11). HF risk increased by 18% (95% CI:1.03–1.35) for every 1 additional standard deviation(SD)of baPWV. Restricted cubic spline results showed statistically significant overall and non-linear associations between AS and HF risk (P < 0.05). The subgroup analysis and sensitivity analysis were consistent with that of total population. AS is an independent risk factor for developing HF in the diabetic population, and AS exhibits a dose-response relationship with HF risk. •AS was an independent risk factor for developing HF in the diabetic population.•AS exhibits a dose-response relationship with HF risk.